148927-39-3Relevant academic research and scientific papers
Synthesis and biological activities of camphor-based non-peptide growth hormone secretagogues
Nargund, Ravi P.,Barakat, Khaled H.,Cheng, Kang,Chan, Wanda W.-S,Butler, Bridget R.,Smith, Roy G.,Patchett, Arthur A.
, p. 1265 - 1270 (2007/10/03)
The synthesis and growth hormone (GH) releasing activities of a novel series of camphor-based non-peptide GH secretagogues is presented. Use of the (R)-nipecotic acid amino side-chain and N terminal derivatization of it with an (R)-(2-hydroxy)propyl group provided a potent secretagogue 18 (EC50 = 90 nM). An o-tolyl piperazine was identified as a good replacement for the spiroindanyl piperidine.
1-(((7,7-Dimethyl-2(S)-(2(S)-amino-4- (methylsulfonyl)butyramido)bicyclo[2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4- (2-methylphenyl)piperazine (L-368,899): An orally bioavailable, non-peptide oxytocin antagonist with potential utility for managing preterm
Williams,Anderson,Ball,Bock,Carroll,Chiu -,Clineschmidt,Culberson,Erb,Evans,Fitzpatrick,Freidinger,Kaufman,Lundell,Murphy,Pawluczyk,Perlow,Pettibone,Pitzenberger,et al.
, p. 565 - 571 (2007/10/02)
Modifications to the previously reported spiroindenylpiperidine camphorsulfonamide oxytocin (OT) antagonist L-366,509 have produced a new series of o-tolylpiperazine (TP) camphorsulfonamides. A number of analogues in the TP series that incorporate a modif
