148932-68-7

Basic information

• Product Name: 2-Amino-3-methoxybenzonitrile
• Synonyms: 2-Amino-3-Methoxy Benzonitrile;Benzonitrile, 2-amino-3-methoxy-;Benzonitrile, 2-amino-3-methoxy- (9CI)
• CAS NO: 148932-68-7
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• EINECS: 201-215-5
• Product Categories: AMINEPRIMARY
• Mol File: 148932-68-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 286.928 °C at 760 mmHg
• Flash Point: 127.33 °C
• Appearance: /
• Density: 1.176 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.75±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-3-methoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-methoxybenzonitrile(148932-68-7)
• EPA Substance Registry System: 2-Amino-3-methoxybenzonitrile(148932-68-7)

Safety Data

• Hazardous Substances Data: 148932-68-7(Hazardous Substances Data)

Usage

Uses

2-Amino-3-methoxybenzonitrile is used to prepare cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands. It is also used to prepare 2- and 3-aminobenzo[b]thiophenes as antimitotic agents.

InChI:InChI=1/C8H8N2O/c1-11-7-4-2-3-6(5-9)8(7)10/h2-4H,10H2,1H3

Upstream product

• 1527-89-5 3-methoxybenzonitrile 
• 15865-57-3 2-nitro-3-methoxybenzoyl chloride 
• 4920-80-3 3-methoxy-2-nitrobenzoic acid 
• 99595-85-4 3-methoxy-2-nitro-benzamide 
• 142596-50-7 3-methoxy-2-nitrobenzonitrile 

Downstream Products

• 176718-54-0 2-amino-3-methoxy-5-bromobenzonitrile 
• 939970-65-7 O-ethyl ester of 2-cyano-6-methoxyphenyl dithiocarbonic acid 
• 1093967-06-6 2-amino-5-(isopropylsulfonyl)-3-{[5-(methylthio)pyridin-2-yl]methoxy}benzonitrile 
• 1093967-02-2 2-amino-5-(isopropylsulfonyl)-3-[3-(methylsulfonyl)propoxy]benzonitrile 
• 1093967-00-0 2-amino-5-(isopropylsulfonyl)-3-(2-pyridin-2-ylethoxy)benzonitrile 
• 1093966-99-4 2-amino-3-hydroxy-5-(isopropylsulfonyl)benzonitrile 
• 1093966-98-3 2-amino-3-hydroxy-5-(isopropylthio)benzonitrile 
• 1093966-97-2 2-amino-5-(isopropylthio)-3-methoxybenzonitrile 
• 1012369-81-1 (2-cyano-6-methoxy-phenyl)-carbamic acid ethyl ester 
• 1026065-48-4 1-(2-Cyano-6-methoxy-phenyl)-3-pentyl-urea 
• 148726-44-7 1-(2-Cyano-6-hydroxy-phenyl)-3-pentyl-urea 
• 176718-55-1 2-Amino-5-bromo-3-hydroxybenzonitrile 
• 88791-24-6 2-mercapto-3-methoxybenzonitrile 

Relevant articles and documents

Pyridyl Radical Cation for C?H Amination of Arenes

Electron-transfer photocatalysis provides access to the elusive and unprecedented N-pyridyl radical cation from selected N-substituted pyridinium reagents. The resulting C(sp2)?H functionalization of (hetero)arenes furnishes versatile intermediates for the development of valuable aminated aryl scaffolds. Mechanistic studies that include the first spectroscopic evidence of a spin-trapped N-pyridyl radical adduct implicate SET-triggered, pseudo-mesolytic cleavage of the N?X pyridinium reagents mediated by visible light.

Structure-activity relationship of a series of phenylureas linked to 4- phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O- acyltransferase with antiatherosclerotic activity. 2

In our continuing search to find systemically bioavailable ACAT (acyl- CoA:cholesterol O-acyl-transferase) inhibitors with more potent antiatherosclerotic effect than N-[2-(dimethylamino)-6-[3-(5-methyl-4- phenyl-1H-imidazol-1-yl)propoxy]phenyl]-N'-pentyl