99595-85-4Relevant articles and documents
Quantum Tunneling Mediated Interfacial Synthesis of a Benzofuran Derivative
Paintner, Tobias,Bj?rk, Jonas,Du, Ping,Klyatskaya, Svetlana,Paszkiewicz, Mateusz,Hellwig, Raphael,Uphoff, Martin,?ner, Murat A.,Cuniberto, Edoardo,Deimel, Peter S.,Zhang, Yi-Qi,Palma, Carlos-Andres,Allegretti, Francesco,Ruben, Mario,Barth, Johannes V.,Klappenberger, Florian
supporting information, p. 11285 - 11290 (2019/07/15)
Reaction pathways involving quantum tunneling of protons are fundamental to chemistry and biology. They are responsible for essential aspects of interstellar synthesis, the degradation and isomerization of compounds, enzymatic activity, and protein dynami
QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS
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Page/Page column 107, (2010/06/15)
The invention is directed to quinazoline compounds that can inhibit the bioactivity of one or more kinase enzymes, including a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Fit kinase, an Aurora kinase, or a Src kinase, or any combination thereof; to methods of use of those compounds; and to methods of preparation of those compounds. The inventive compounds can be used in the treatment of malconditions including cardiovascular disease, neurogenic pain, hypertension, atherosclerosis, angina, stroke, arterial obstruction, peripheral arterial disease, erectile dysfunction, acute and chronic pain, dementia, Alzheimer's disease, Parkinson's disease, neuronal degeneration, asthma, amyotrophic lateral sclerosis, spinal cord injury, rheumatoid arthritis, osteoarthritis, osteoporosis, psoriasis, cerebral vasospasm, open angle glaucoma, multiple sclerosis, pulmonary hypertension, acute respiratory distress syndrome, inflammation, diabetes, urinary organ diseases and benign prostatic hypertrophy (BPH), metastasis, cancer, glaucoma, ocular hypertension, retinopathy, autoimmune disease, viral infection, or myocardial pathology.
Method of treating a patient having precancerous lesions with phenyl quinazolinone derivatives
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, (2008/06/13)
Derivatives of 2-phenyl quinazolinones are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
