148933-50-0

Upstream product

• 126788-90-7 <4R,5S>-3-<1-oxo-2-<(4-methoxyphenyl)methoxy>ethyl>-4-methyl-5-phenyl-2-oxazolidinone 
• 148933-49-7 (E)-(2R,5S,7S)-9-Iodo-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-non-8-enal 
• 168777-77-3 1-Methoxy-4-((E)-(2R,5S,7S)-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-9-trimethylsilanyl-non-8-enyloxymethyl)-benzene 
• 148933-48-6 {(E)-(1S,3S)-5-Iodo-3-methoxy-1-[(R)-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-4-methyl-pent-4-enyloxy}-triisopropyl-silane 
• 168777-76-2 (E)-(3S,5S,8R)-3-Methoxy-9-(4-methoxy-benzyloxy)-2,8-dimethyl-1-trimethylsilanyl-non-1-en-5-ol 
• 148933-54-4 (E)-(2R,5S,7S)-9-Iodo-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-non-8-en-1-ol 
• 148933-46-4 [(E)-(S)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methoxy-2-methyl-but-1-enyl]-trimethyl-silane 
• 148933-52-2 (E)-(S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methyl-4-trimethylsilanyl-but-3-en-2-ol 
• 148933-45-3 (E)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methyl-4-trimethylsilanyl-but-3-en-2-one 
• 148933-47-5 ((E)-(S)-3-Methoxy-2-methyl-4-(R)-oxiranyl-but-1-enyl)-trimethyl-silane 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 

Relevant academic research and scientific papers

A Highly Convergent Strategy Towards Rapamycin. Stereoselective Construction of the C8-C18 Fragment

A strategy for a total synthesis of the immunosuppressant agent rapamycin 1 is outlined and the stereoselective construction of a suitably functionalized C8-C18 fragment 2 is described.