A Highly Convergent Strategy Towards Rapamycin. Stereoselective Construction of the C8-C18 Fragment

DOI: 10.1039/c39930000617

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 617 - 618 (1993)

Update date:2022-08-04

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Authors:

Piscopio, A. D.

Minowa, N.

Chakraborty, T. K.

Koide, K.

Bertinato, P.

Nicolaou, K. C.

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Article abstract of DOI:10.1039/c39930000617

A strategy for a total synthesis of the immunosuppressant agent rapamycin 1 is outlined and the stereoselective construction of a suitably functionalized C⁸-C¹⁸ fragment 2 is described.

Full text of DOI:10.1039/c39930000617

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