148960-51-4

Basic information

• Product Name: Benzenamine, 4-[2-(phenylsulfonyl)ethyl]-
• CAS NO: 148960-51-4
• Molecular Formula: C14H15 N O2 S
• Molecular Weight: 261.345
• Mol File: 148960-51-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-[2-(phenylsulfonyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-[2-(phenylsulfonyl)ethyl]-(148960-51-4)
• EPA Substance Registry System: Benzenamine, 4-[2-(phenylsulfonyl)ethyl]-(148960-51-4)

Safety Data

• Hazardous Substances Data: 148960-51-4(Hazardous Substances Data)

Upstream product

• 873-55-2 sodium benzenesulfonate 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 340041-90-9 4-nitrophenyl-2-(4-benzenesulfonylhydrazide)ethane 

Downstream Products

• 868618-78-4 oxo(2-{4-[2-(phenylsulfonyl)ethyl]phenyl}hydrazino)acetic acid 
• 143322-58-1 eletriptan 

Relevant articles and documents

High Turnover Pd/C Catalyst for Nitro Group Reductions in Water. One-Pot Sequences and Syntheses of Pharmaceutical Intermediates

Commercially available Pd/C can be used as a catalyst for nitro group reductions with only 0.4 mol % Pd loading. The reaction can be performed using either silane as a transfer hydrogenating agent or simply a hydrogen balloon (μ1 atm pressure). With this technology, a series of nitro compounds was reduced to the desired amines in high chemical yields. Both the catalyst and surfactant were recycled several times without loss of reactivity.

MODIFIED FISCHER INDOLE SYNTHESIS OF ELETRIPTAN

The present invention relates to a new process for the preparation of eletriptan (I), or its enantiomer comprising a modified Fischer indole synthesis, namely the reaction of a compound of formula (II), wherein R1 is a suitable hydrazine protecting group, with a compound of formula (III) wherein R2is an aldehyde group (-CHO) or the functional equivalent thereof.