148960-93-4Relevant academic research and scientific papers
Facile synthesis of the 'tricarbonyl' subunit in the immunosuppressant rapamycin
Pattenden,Tankard,Cherry
, p. 2677 - 2680 (1993)
A concise synthetic route to the tricarbonyl subunit (3a) in the immunosuppressant rapamycin (2), based on ruthenium-catalysed oxidation of an acetylenic amide precursor (17) is described, viz (17) → (18) → (20).
