Facile synthesis of the 'tricarbonyl' subunit in the immunosuppressant rapamycin

DOI: 10.1016/S0040-4039(00)77654-4

Source and publish data:

Tetrahedron Letters p. 2677 - 2680 (1993)

Update date:2022-08-03

Topics:

Authors:

Pattenden

Tankard Tankard

Cherry Cherry

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Article abstract of DOI:10.1016/S0040-4039(00)77654-4

A concise synthetic route to the tricarbonyl subunit (3a) in the immunosuppressant rapamycin (2), based on ruthenium-catalysed oxidation of an acetylenic amide precursor (17) is described, viz (17) → (18) → (20).

Full text of DOI:10.1016/S0040-4039(00)77654-4

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