148979-72-0

Basic information

• Product Name: 1-DEOXY-D-RIBULOSE
• Synonyms: 1-DEOXY-D-RIBULOSE
• CAS NO: 148979-72-0
• Molecular Formula: C5H10O4
• Molecular Weight: 134.13
• Mol File: 148979-72-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-DEOXY-D-RIBULOSE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-DEOXY-D-RIBULOSE(148979-72-0)
• EPA Substance Registry System: 1-DEOXY-D-RIBULOSE(148979-72-0)

Safety Data

• Hazardous Substances Data: 148979-72-0(Hazardous Substances Data)

Usage

Uses

1-Deoxy-D-ribulose (cas# 148979-72-0) is a compound useful in organic synthesis.

Upstream product

• 1187452-05-6 (Z)-(4R,5R)-1-n-butylamino-5-hydroxy-4,6-O-dibenzyl-hex-1-en-3-one 
• 1187452-04-5 (Z)-(4R,5R)-1-benzylamino-5-hydroxy-4,6-O-dibenzyl-hex-1-en-3-one 
• 1187452-03-4 (Z)-(4S,5R)-1-n-butylamino-5-hydroxy-4,6-O-dibenzyl-hex-1-en-3-one 
• 1187452-02-3 (Z)-(4S,5R)-1-benzylamino-5-hydroxy-4,6-O-dibenzyl-hex-1-en-3-one 
• 149056-73-5 (S)-1-[(4R,4'R,5'R)-2,2,2'-tetramethyl-4,4'-bi(1,3-dioxolan)-5-yl]ethanol 
• 94284-20-5 1-deoxy-3,4:5,6-di-O-isopropylidene-D-arabino-hex-2-ulose 
• 4435-02-3 3,4:5,6-di-O-isopropylidene-D-glucose diethyl dithioacetal 
• 453-17-8 D-Glyceraldehyde 
• 339-71-9 2-keto-butyrate 
• 141-46-8 Glycolaldehyde 
• 5077-67-8 1-Hydroxy-2-butanone 

Relevant articles and documents

Synthesis of threo- and erythro-configured trihydroxy open chain lipophilic ketones as possible anti-mycobacterial agents

A series of threo- and erythro-configured open-chain trihydroxy ketones was synthesized starting from L- and D-ascorbic acid respectively as the starting material, through the use of Grignard reactions for the requisite C[sbnd]C bond formations. The lipophilic ketones were screened against Mycobacteriumtuberculosis for anti-proliferative activity. The lipophilic ketones with tetradecyl alkyl side chains were found to be moderately active against cell proliferation.

Donor Promiscuity of a Thermostable Transketolase by Directed Evolution: Efficient Complementation of 1-Deoxy-d-xylulose-5-phosphate Synthase Activity

Enzymes catalyzing asymmetric carboligation reactions typically show very high substrate specificity for their nucleophilic donor substrate components. Structure-guided engineering of the thermostable transketolase from Geobacillus stearothermophilus by directed in vitro evolution yielded new enzyme variants that are able to utilize pyruvate and higher aliphatic homologues as nucleophilic components for acyl transfer instead of the natural polyhydroxylated ketose phosphates or hydroxypyruvate. The single mutant H102T proved the best hit toward 3-methyl-2-oxobutyrate as donor, while the double variant H102L/H474S showed highest catalytic efficiency toward pyruvate as donor. The latter variant was able to complement the auxotrophic deficiency of Escherichia coli cells arising from a deletion of the dxs gene, which encodes for activity of the first committed step into the terpenoid biosynthesis, offering the chance to employ a growth selection test for further enzyme optimization.

Hydrodeamination of β-enamino ketones to 1,2-dideoxy-d-threo-3-hexulose via palladium

β-Enamino ketones were successfully synthesized in good to excellent yields by reaction of hex-1-en-3-uloses with amines. After hydrogenation on palladium catalyst, β-enamino ketones effectively underwent hydrodeamination and were converted to the corresp