148979-72-0

Usage

Uses

1-Deoxy-D-ribulose (cas# 148979-72-0) is a compound useful in organic synthesis.

Upstream product

• 141-46-8 Glycolaldehyde 
• 5077-67-8 1-Hydroxy-2-butanone 
• 453-17-8 D-Glyceraldehyde 
• 339-71-9 2-keto-butyrate 
• 1187452-05-6 (Z)-(4R,5R)-1-n-butylamino-5-hydroxy-4,6-O-dibenzyl-hex-1-en-3-one 
• 1187452-04-5 (Z)-(4R,5R)-1-benzylamino-5-hydroxy-4,6-O-dibenzyl-hex-1-en-3-one 
• 1187452-03-4 (Z)-(4S,5R)-1-n-butylamino-5-hydroxy-4,6-O-dibenzyl-hex-1-en-3-one 
• 1187452-02-3 (Z)-(4S,5R)-1-benzylamino-5-hydroxy-4,6-O-dibenzyl-hex-1-en-3-one 
• 149056-73-5 (S)-1-[(4R,4'R,5'R)-2,2,2'-tetramethyl-4,4'-bi(1,3-dioxolan)-5-yl]ethanol 
• 94284-20-5 1-deoxy-3,4:5,6-di-O-isopropylidene-D-arabino-hex-2-ulose 
• 4435-02-3 3,4:5,6-di-O-isopropylidene-D-glucose diethyl dithioacetal 

Relevant academic research and scientific papers

Synthesis of threo- and erythro-configured trihydroxy open chain lipophilic ketones as possible anti-mycobacterial agents

A series of threo- and erythro-configured open-chain trihydroxy ketones was synthesized starting from L- and D-ascorbic acid respectively as the starting material, through the use of Grignard reactions for the requisite C[sbnd]C bond formations. The lipophilic ketones were screened against Mycobacteriumtuberculosis for anti-proliferative activity. The lipophilic ketones with tetradecyl alkyl side chains were found to be moderately active against cell proliferation.

Photolysis of 2-azi-2-deoxy-D-arabino-hexitol and analogous hexitols; the ineffectiveness of certain carbohydrate diazirines as photoaffinity labels

Three diazirines 2-azi-2-deoxy-D-arabino-hexitol (4), its 1-deoxy analogue (5), and 3-azi-3,6-dideoxy-L-xylo-hexitol (9) were synthesised and their products of photolysis analysed by TLC.Diazirine 4 gave exclusively 2-deoxy-D-arabino-hexose (12), 5 gave predominantly 1,2-dideoxy-D-erythro-3-hexulose (10) and 1-deoxy-D-glucitol (11), and 9 did not yield any main product.Carrying out the irradiation of 4 in D2O gave selectively (2S)-2-deoxy-D-arabino-(2-2H)hexose (12a).The results indicate that photolysis of a diazirine flanked by a hydroxymethyl group, as in compound 4, leads to a rapid and stereoselective intramolecular reaction of the intermediate.This may be an explanation of why compound 4 is ineffective as a photoaffinity reagent for mannitol permease (D-mannitol-specific enzyme II) of the E. coli phosphotransferase system for which it is a substrate.A secondary hydroxymethylene group has a less pronounced effect and still allows some reaction with the medium.

Donor Promiscuity of a Thermostable Transketolase by Directed Evolution: Efficient Complementation of 1-Deoxy-d-xylulose-5-phosphate Synthase Activity

Enzymes catalyzing asymmetric carboligation reactions typically show very high substrate specificity for their nucleophilic donor substrate components. Structure-guided engineering of the thermostable transketolase from Geobacillus stearothermophilus by directed in vitro evolution yielded new enzyme variants that are able to utilize pyruvate and higher aliphatic homologues as nucleophilic components for acyl transfer instead of the natural polyhydroxylated ketose phosphates or hydroxypyruvate. The single mutant H102T proved the best hit toward 3-methyl-2-oxobutyrate as donor, while the double variant H102L/H474S showed highest catalytic efficiency toward pyruvate as donor. The latter variant was able to complement the auxotrophic deficiency of Escherichia coli cells arising from a deletion of the dxs gene, which encodes for activity of the first committed step into the terpenoid biosynthesis, offering the chance to employ a growth selection test for further enzyme optimization.

Broadening deoxysugar glycodiversity: Natural and engineered transaldolases unlock a complementary substrate space

The majority of prokaryotic drugs are produced in glycosylated form, with the deoxygenation level in the sugar moiety having a profound influence on the drug's bioprofile. Chemical deoxygenation is challenging due to the need for tedious protective group manipulations. For a direct biocatalytic de novo generation of deoxysugars by carboligation, with regiocontrol over deoxygenation sites determined by the choice of enzyme and aldol components, we have investigated the substrate scope of the F178Y mutant of transaldolase B, TalBF178Y, and fructose 6-phosphate aldolase, FSA, from E. coli against a panel of variously deoxygenated aldehydes and ketones as aldol acceptors and donors, respectively. Independent of substrate structure, both enzymes catalyze a stereospecific carboligation resulting in the D-threo configuration. In combination, these enzymes have allowed the preparation of a total of 22 out of 24 deoxygenated ketose-type products, many of which are inaccessible by available enzymes, from a [3 -8] substrate matrix. Although aliphatic and hydroxylated aliphatic aldehydes were good substrates, D-lactaldehyde was found to be an inhibitor possibly as a consequence of inactive substrate binding to the catalytic Lys residue. A 1-hydroxy-2-alkanone moiety was identified as a common requirement for the donor substrate, whereas propanone and butanone were inactive. For reactions involving dihydroxypropanone, TalBF178Y proved to be the superior catalyst, whereas for reactions involving 1-hydroxybutanone, FSA is the only choice; for conversions using hydroxypropanone, both TalBF178Y and FSA are suitable. Structure-guided mutagenesis of Ser176 to Ala in the distant binding pocket of TalBF178Y, in analogy with the FSA active site, further improved the acceptance of hydroxypropanone. Together, these catalysts are valuable new entries to an expanding toolbox of biocatalytic carboligation and complement each other well in their addressable constitutional space for the stereospecific preparation of deoxysugars.

Hydrodeamination of β-enamino ketones to 1,2-dideoxy-d-threo-3-hexulose via palladium

β-Enamino ketones were successfully synthesized in good to excellent yields by reaction of hex-1-en-3-uloses with amines. After hydrogenation on palladium catalyst, β-enamino ketones effectively underwent hydrodeamination and were converted to the corresp