149010-73-1

Upstream product

• 51186-41-5 methyl N^δ-(tert-butoxycarbonyl)-L-ornithinate 
• 149010-53-7 4-<2-(2,4-Diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid 

Downstream Products

• 162007-20-7 methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(3,5-dimethoxycarbonylbenzenesulfonyl)-L-ornithinate 
• 1054612-05-3 2-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-5-(3,4,5-trimethoxy-benzoylamino)-pentanoic acid methyl ester 
• 1054641-89-2 5-(4-acetylamino-benzoylamino)-2-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanoic acid methyl ester 
• 162007-19-4 methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(2-methoxycarbonylbenzenesulfonyl)-L-ornithinate 
• 1053735-50-4 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester 
• 162007-15-0 methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(4-fluorophenylcarbamoyl)-L-ornithinate 
• 162007-21-8 methyl N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-N^δ-(4-toluenesulfonyl)-L-ornithinate 
• 1053248-37-5 3-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-acrylic acid methyl ester 

Relevant academic research and scientific papers

Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. III. Synthesis and biological properties of N(ω)-masked ornithine analogs

The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutam ic acid (1b, TNP-351) and the related compound (1a), was replaced with various N(ω)-acyl-, sulfonyl-, carbamoyl- and aryl-2,ω-diaminoalkanoic acids,