162007-19-4Relevant articles and documents
Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. III. Synthesis and biological properties of N(ω)-masked ornithine analogs
Itoh, Fumio,Yoshioka, Yoshio,Yukishige, Koichi,Yoshida, Sei,Ootsu, Koichiro,Akimoto, Hiroshi
, p. 1270 - 1280 (2007/10/03)
The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutam ic acid (1b, TNP-351) and the related compound (1a), was replaced with various N(ω)-acyl-, sulfonyl-, carbamoyl- and aryl-2,ω-diaminoalkanoic acids,