149022-18-4 Usage
Uses
DL-threo-PPMP Hydrochloride is a ceramide analog which inhibts glucosylceramide synthase. Used to study the role of glucosylceramide synthase in cell growth and apoptosis.
Definition
ChEBI: An N-[1-hydroxy-3-(morpholin-4-yl)-1-phenylpropan-2-yl]hexadecanamide in which both stereocentres have R configuration.
Check Digit Verification of cas no
The CAS Registry Mumber 149022-18-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,0,2 and 2 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 149022-18:
(8*1)+(7*4)+(6*9)+(5*0)+(4*2)+(3*2)+(2*1)+(1*8)=114
114 % 10 = 4
So 149022-18-4 is a valid CAS Registry Number.
InChI:InChI=1/C29H50N2O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-20-28(32)30-27(25-31-21-23-34-24-22-31)29(33)26-18-15-14-16-19-26/h14-16,18-19,27,29,33H,2-13,17,20-25H2,1H3,(H,30,32)/t27-,29-/m1/s1
149022-18-4Relevant articles and documents
Methods for treating conditions modulated by lactosylceramide
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, (2008/06/13)
The present invention includes methods for treatment and prophylaxis of conditions associated with lactosylceramide. The methods generally provide for administration to a mammal, particularly a human, of a therapeutically effective amount of a compound that increases enzymatic activity of UDPGal:GlcCerβ1→4 galactosylceramide (GalT-2). In vitro and in vivo assays for detecting compounds with therapeutic capacity to modulate GalT-2 are also provided.
