149096-32-2Relevant academic research and scientific papers
INHIBITORS OF AKT ACTIVITY
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Page/Page column 140, (2010/11/25)
The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
ALKYLATION OF METHYL IMIDAZOLE-4(5)-CARBOXYLATE WITH 1-BROMOPROPANE AND ETHYL BENZENESULFONATE
Mishin, M.A.,Poznyakova, L.N.,Piotrovskii, L.B.,Erusalimskii, G.B.
, p. 2126 - 2129 (2007/10/02)
Methyl 1-propylimidazole-4- and 1-propylimidazole-5-carboxylates were obtained in the ratio of ca.2:1 by alkylation of methyl imidazole-4(5)-carboxylate with 1-bromopropane in an alkaline medium.Reaction of methyl imidazole-4(5)-carboxylate with ethyl benzenesulfonate gave a 1:1 mixture of methyl 1-ethylimidazole-4- and 1-ethylimidazole-5-carboxylates.The regioselectivity of the alkylation may be due to the fact that the reaction is entropy-controlled.
