1491-12-9Relevant academic research and scientific papers
Enantioselective synthesis of (-)-curcumanolide A using enzymatic transesterification of meso-spirodiol
Fujita, Toshiaki,Tanaka, Masakazu,Norimine, Yoshihiko,Suemune, Hiroshi,Sakai, Kiyoshi
, p. 3824 - 3830 (1997)
meso-Spirodiol 12 and spirodiacetate 13 were stereoselectively prepared using π-face selective Grignard addition to norbornanone 7. Asymmetric transesterification of meso-diol and hydrolysis of meso-diacetate were studied using lipases. Pseudomonas fluorescens lipase-catalyzed transesterification of meso-diol 12 afforded the monoacetate (-)-21 of high enantiomeric excess (> 99% ee). The formal synthesis of (-)-curcumanolide A has been achieved from the optically active (-)-21.
HEPATITIS C VIRUS INHIBITORS
-
Page/Page column 74-75, (2012/03/09)
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment o
