149105-11-3

Usage

Preparation

Obtained by heating to 180° under nitrogen a mixture of 4-methoxy-3-(trifluoromethyl)acetophenone and pyridinium chloride (39%).

Upstream product

• 400629-06-3 2-(trifluoromethyl)phenyl acetate 
• 99-93-4 4-Hydroxyacetophenone 
• 2926-29-6 Langlois reagent 
• 444-30-4 2-(trifluoromethyl)phenol 

Downstream Products

• 1100767-72-3 1-[4-(pyridin-4-ylmethoxy)-3-trifluoromethyl-phenyl]-ethanone trifluoroacetate 
• 1100767-76-7 4-(4-acetyl-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester 
• 1005515-08-1 1-(3-Bromo-4-hydroxy-5-trifluoromethylphenyl)ethanone 
• 1162128-65-5 1-(4-(hexyloxy)-3-(trifluoromethyl)phenyl)ethanone 
• 1005515-09-2 1-Bromo-5-(1,1-dimethoxyethyl)-2-methoxy-3-trifluoromethylbenzene 
• 1005515-10-5 4-[5-(1,1-Dimethoxyethyl)-2-methoxy-3-trifluoromethylphenyl]morpholine 
• 1005515-11-6 2-bromo-1-(4-methoxy-3-morpholin-4-yl-5-trifluoromethylphenyl)ethanone 
• 1285575-67-8 1-(4-methoxymethoxy-3-trifluoromethylphenyl)ethanone 
• 536975-35-6 4-benzyloxy-3-trifluoromethyl benzoic acid 
• 115933-49-8 4-benzyloxy-3-trifluoromethylbenzoic acid methyl ester 
• 1029097-91-3 4-benzyloxy-3-trifluoromethylbenzoyl chloride 
• 1285575-68-9 3-(4-benzyloxy-3-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole 
• 1285575-71-4 3-(4-benzyloxy-3-trifluoromethylbenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole 
• 115933-50-1 methyl 4-hydroxy-3-(trifluoromethyl)benzoate 

Relevant academic research and scientific papers

Regioselective C-H Trifluoromethylation of Aromatic Compounds by Inclusion in Cyclodextrins

A regioselective radical C-H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C-H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD. 1H NMR experiments indicated that the regioselectivity was controlled by the inclusion of a substrate inside the CD cavity.

Cu and hydroquinone for the trifluoromethylation of unprotected phenols

Fluorination and trifluoromethylation are indispensable tools in the preparation of modern pharmaceuticals and APIs. Herein we present a concept for the introduction of a trifluoromethyl group into unprotected phenols employing catalytic copper(I) iodide

NOVEL PHENOL DERIVATIVE

Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt t