149105-13-5

Basic information

• Product Name: Methanesulfonic acid, trifluoro-, 4-acetyl-2-methoxyphenyl ester
• CAS NO: 149105-13-5
• Molecular Formula: C10H9F3O5S
• Molecular Weight: 298.24
• Mol File: 149105-13-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid, trifluoro-, 4-acetyl-2-methoxyphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid, trifluoro-, 4-acetyl-2-methoxyphenyl ester(149105-13-5)
• EPA Substance Registry System: Methanesulfonic acid, trifluoro-, 4-acetyl-2-methoxyphenyl ester(149105-13-5)

Safety Data

• Hazardous Substances Data: 149105-13-5(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 

Downstream Products

• 1246560-12-2 1-(3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethan-1-one 
• 339526-67-9 [2-methoxy-4-(4-methyl-2,5-dioxo-imidazolidin-4-yl)-phenyl]-phosphonic acid diethyl ester 
• 669091-12-7 2-bromo-1-[3-methoxy-4-(pyridin-2-yl)phenyl]ethanone 
• 669091-11-6 1-[3-methoxy-4-(pyridin-2-yl)phenyl]ethanone 

Relevant articles and documents

SUBSTITUTED PYRAZOLOPYRIMIDINES AND SUBSTITUTED PURINES AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS

The present disclosure provides compounds having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein X1, X2, X11, X12, R1, R3, R5, R5', R6, and R7 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to inhibit a USP1 protein and/or to treat a disorder responsive to the inhibition of USP1 proteins and USP1 activity. Compounds of the present disclosure are especially useful for treating cancer.

SUBSTITUTED BICYCLIC HCV INHIBITORS

Provided herein are compounds, pharmaceutical compositions and combination therapies for treatment of hepatitis C.

A polystyrene-supported triflating reagent for the synthesis of aryl triflates

An insoluble polystyrene-supported triflating reagent has been prepared by suspension co-polymerization of N-(4-vinylphenyl)trifluoromethanesulphonimide, styrene and the JandaJel cross-linker. This reagent, in the presence of triethylamine, allows for the efficient synthesis of aryl triflates from a wide range of phenols in a process that permits the desired product to be isolated from the reaction mixture in essentially pure form via several filtration and concentration operations. Adding to the utility of this reagent is its ability to be easily recovered, regenerated and reused. Both soluble and insoluble bifunctional polymers containing trialkylamine moieties in addition to triflimide groups were also prepared and examined as triflating reagents. Unfortunately these reagents afforded only modest yields of the desired products in representative reactions. Graphical Abstract.