149107-84-6

Basic information

• Product Name: 7,10-Bis[O-(triethylsilyl)]-10-deacetyl Baccatin III
• Synonyms: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4a,8,13,13-tetramethyl-4,6-bis[(triethylsilyl)oxy]-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one-;7,10-Bis[O-(triethylsilyl)]-10-deacetyl Baccatin III;(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4a,8,13,13-tetraMethyl-4,6-bis[(triethylsilyl)oxy]-7,11-Methano-5H-cyclod
• CAS NO: 149107-84-6
• Molecular Formula: C₄₁H₆₄O₁₀Si₂
• Molecular Weight: 773.11
• Product Categories: Chiral Reagents;Heterocycles;Chiral Reagents, Heterocycles
• Mol File: 149107-84-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Refractive Index: 1.542
• Solubility: Chloroform, Ethyl Acetate
• CAS DataBase Reference: 7,10-Bis[O-(triethylsilyl)]-10-deacetyl Baccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 7,10-Bis[O-(triethylsilyl)]-10-deacetyl Baccatin III(149107-84-6)
• EPA Substance Registry System: 7,10-Bis[O-(triethylsilyl)]-10-deacetyl Baccatin III(149107-84-6)

Safety Data

• Hazardous Substances Data: 149107-84-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Intermediate for the preparation of Docetaxel

InChI:InChI=1/C41H64O10Si2/c1-12-52(13-2,14-3)50-30-23-31-40(25-47-31,49-27(8)42)34-36(48-37(45)28-21-19-18-20-22-28)41(46)24-29(43)26(7)32(38(41,9)10)33(35(44)39(30,34)11)51-53(15-4,16-5)17-6/h18-22,29-31,33-34,36,43,46H,12-17,23-25H2,1-11H3/t29-,30-,31+,33+,34?,36-,39+,40-,41+/m0/s1

Upstream product

• 32981-86-5 10-deacetylbaccatin III 
• 994-30-9 triethylsilyl chloride 
• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 

Downstream Products

• 114915-20-7 Docetaxel 

Relevant articles and documents

Docetaxel derivative and pharmaceutical composition and application thereof

The invention discloses a docetaxel derivative as shown in general formula (I), pharmaceutically acceptable composition containing the docetaxel derivative and application of the docetaxel derivativein the preparation of antitumor drugs and especially in

PROCESS FOR PREPARING TAXOIDS FROM BACCATIN DERIVATIVES USING LEWIS ACID CATALYST

The present invention relates to a process of preparing a taxoid (X) by reacting a protected baccatin derivative (B) with a β-lactam (C) in the presence of one or more Lewis acids and a base agent. The present invention also relates to a process of preparing the protected baccatin derivative (B) from a baccatin derivative (A) comprising a protection reaction catalyzed by one or more Lewis acids with an optional base agent.

Beta-Lactams useful for preparation of substituted isoserine esters using metal alkoxides

β-lactams are disclosed which are useful for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted esters by reaction with a metal alkoxide.