149139-07-1

Basic information

• Product Name: 2-(4-chlorophenyl)-10-propionyl-5,6-dihydro<1>benzothiepino<5,4-c>pyridazin-3(2H)-one
• CAS NO: 149139-07-1
• Molecular Weight: 396.897
• Mol File: 149139-07-1.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-10-propionyl-5,6-dihydro<1>benzothiepino<5,4-c>pyridazin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-10-propionyl-5,6-dihydro<1>benzothiepino<5,4-c>pyridazin-3(2H)-one(149139-07-1)
• EPA Substance Registry System: 2-(4-chlorophenyl)-10-propionyl-5,6-dihydro<1>benzothiepino<5,4-c>pyridazin-3(2H)-one(149139-07-1)

Safety Data

• Hazardous Substances Data: 149139-07-1(Hazardous Substances Data)

Upstream product

• 79-03-8 propionyl chloride 
• 118288-65-6 2-(4-chlorophenyl)-5,6-dihydro-[1]benzothiepino[5,4-c]-pyridazin-3(2H)-one 

Relevant articles and documents

Synthesis and structure-activity analysis of 2-(4-chlorophenyl)-5,6-dihydrothienothiepinopyridazin-3(2H)-ones as ligands for benzodiazepine receptors

A series of 2-(4-chlorophenyl)-5,6-dihydrothienothiepinopyridazin-3(2H)-ones were synthesized and evaluated in vitro for their affinity toward benzodiazepine receptors (BZRs) in rats and for their intrinsic efficacy in the augmentation of the γ-aminobutyric acid (GABA)-induced chloride currents in the dissociated frog sensory neurons.Compounds in wich the 9-position of the condensed-ring system was substituted with alkyl group or bromine had a high affinity toward BZRs.The substituents at the same position also influenced significantly the GABA-induced chloride currents.As the result, 9-alkyl and 9-bromo substutuents would interact with the lipophilic area of BZRs.A series of 2-(4-chlorophenyl)-5,6-dihydrothienothiepinopyridazin-3(2H)-ones exhibited partial and full agonistic activities toward BZRs. benzodiazepine receptor / γ-aminobutyric acid / partial agonist / full agonist / structure activity relationship