149170-33-2Relevant academic research and scientific papers
Synthesis of benzobicycloheptanones via the trap of photogenerated ketene methide intermediate with olefins
Liu, Qiang,Meng, Jiang,Liu, Yang,Yang, Chao,Xia, Wujiong
, p. 8143 - 8155 (2015/03/18)
Irradiation of ortho-formyl dienes with UV light led to benzobicycloheptanones in high yields and chemoselectivities via a photogenerated ketene methide/Diels-Alder cascade reaction. The reaction mechanism was proposed to be a [1,5]-H shift process rather than a radical pathway based on control experiments. DFT calculations indicate that the energy of transition states is responsible for the high chemoselectivity observed in this protocol.
Prins spirocyclization for the synthesis of spiro[isobenzofuran-pyran] derivatives
Reddy, B. V. Subba,Kumar, Harish,Reddy, P. Sivaramakrishna,Singarapu, Kiran Kumar
, p. 4234 - 4238 (2014/07/21)
A Prins cascade process was developed for the synthesis of tetrahydro-3H-spiro[isobenzofuran-pyran] derivatives in good yields and selectivity by the condensation of 3-[2-(hydroxymethyl)phenyl]but-3-en-1-ols with aldehydes or ketones. The reaction proceeds smoothly in the presence of indium(III) trifluoromethanesulfonate (30 mol-%) in dichloroethane at 80 C. This is the first report on the synthesis of tetrahydro-3H-spiro[isobenzofuran- pyran] scaffolds through a Prins cascade reaction. Copyright
Efficient synthesis of polysubstituted isochromanones via a novel photochemical rearrangement
Xia, Wujiong,Shao, Yutian,Gui, Weijun,Yang, Chao
, p. 11098 - 11100 (2011/11/06)
A novel and convenient approach to the synthesis of polysubstituted isochromanones is described. Irradiation of 2-formyl phenylalkeno-derivatives with UV light in benzene solution afforded the corresponding products in up to 98% yield. The possible reaction mechanism is proposed and further supported by the isotopic experiments.
A convenient biphasic process for the monosilylation of symmetrical 1,n- primary diols
Yu, Chengzhi,Liu, Bin,Hu, Longqin
, p. 4281 - 4285 (2007/10/03)
A simple and mild biphasic process was developed for the selective protection of one of two chemically equivalent primary hydroxyl groups in 1,n-diols using t-butyldiphenyl silyl chloride in diisopropyl ethyl amine and dimethyl formamide. (C) 2000 Elsevier Science Ltd.
Prostaglandin analogs
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, (2008/06/13)
Thromboxane receptor antagonist activity is exhibited by compounds of the formula STR1 wherein: V is --(CH 2) m --, --O--, or STR2 but if V is --O--or STR3 R 3 and R 4 must complete an aromatic ring; W is --(CH 2) 2 --, --CH CH-- or phenylene;X is a single bond, --CH CH--, --(CH 2) n --, or --O--(CH 2) n --; or X is branched alkylene or --O--branched alkylene wherein W is linked to Y through a chain n carbon atoms long;Y is --CO 2 H, --CO 2 alkyl, --CO 2 alkali metal, --CH 2 OH, --CONHSO 2 R 5, --CONHR 6, or --CH 2 -5-tetrazolyl;Z is O or NH;R 3 and R 4 are each independently hydrogen or alkyl or R 3 and R 4 together complete a ring optionally substituted through a ring carbon with a halo, lower alkyl, phenyl, halo (lower alkyl), halophenyl, oxo or hydroxyl group; and the remaining symbols are as defined in the specification.
The chemical synthesis of C-ring aryl taxoids
Nicolaou,Claiborne, Christopher F.,Paulvannan, Kumarapandian,H. D. Postema, Maarten,Guy, Rodney K.
, p. 399 - 409 (2007/10/03)
We designed and targeted for synthesis the C-ring aryl taxoids 2a-c in order to develop methods for the construction of the taxoid skeleton and to test their cytotoxicity against tumor cells. Compound 2a was synthesized by a convergent route from hydrazon
