147377-67-1

Upstream product

• 55479-94-2 2-(hydroxymethyl)benzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 175158-50-6 2-(tert-Butyl-diphenyl-silanyloxymethyl)-benzaldehyde 
• 149170-33-2 (2-((tert-butyldiphenylsilyloxy)methyl)phenyl)methanol 
• 87-41-2 2-benzofuran-1(3H)-one 
• 59868-79-0 1,3-dihydroisobenzofuran-1-ol 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 612-14-6 phthalyl alcohol 

Downstream Products

• 148117-58-2 Acetic acid (E)-3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-allyl ester 
• 148117-51-5 Acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2,3-dihydroxy-propyl ester 
• 148117-59-3 Acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2,3-bis-methoxymethoxy-propyl ester 
• 86867-62-1 (E)-3-(2-formylphenyl)propenoic acid ethyl ester 
• 147377-88-6 (E)-2-acetoxy-6-(2-tert-butyldimethylsilyloxymethylphenyl)-3-methylhex-3-ene 
• 147377-72-8 ethyl (E)-5-(2-tert-butyldimethylsilyloxymethylphenyl)-2-methylpent-2-enoate 
• 147377-85-3 (E)-1-acetoxy-5-(2-tert-butyldimethylsilyloxymethylphenyl)-2-methylpent-2-ene 
• 147377-87-5 (E)-2-acetoxy-6-(2-tert-butyldimethylsilyloxymethylphenyl)hex-3-ene 

Relevant academic research and scientific papers

Squaramide-catalyzed asymmetric intramolecular oxa-michael reaction of α,β-unsaturated carbonyls containing benzyl alcohol: Construction of chiral 1-substituted phthalans

Organocatalytic enantioselective intramolecular oxa-Michael reactions of benzyl alcohol bearing α,β-unsaturated carbonyls as Michael acceptors are presented herein. Using cinchona squaramide-based organocatalyst, enones as well as α,βunsaturated esters containing benzyl alcohol provided their corresponding 1,3-dihydroisobenzofuranyl-1-methylene ketones and 1,3-dihydroisobenzofuranyl-1-methylene esters in excellent yields with high enantioselectivities. In addition, enantioenriched 1,3-dihydroisobenzofuranyl-1-methylene ketone could be obtained from the Wittig/oxa-Michael reaction cascade of 1,3-dihydro-2-benzofuran-1-ol.

Efficient synthesis of polysubstituted isochromanones via a novel photochemical rearrangement

A novel and convenient approach to the synthesis of polysubstituted isochromanones is described. Irradiation of 2-formyl phenylalkeno-derivatives with UV light in benzene solution afforded the corresponding products in up to 98% yield. The possible reaction mechanism is proposed and further supported by the isotopic experiments.

New Synthetic Strategy for the Construction of the BCD Ring System of Tanshinones

Employing a strategy for the construction of fused furans based on an intramolecular dipolar cycloaddition reaction of nitrile oxide, the BCD ring system 3 found in the tanshinone family as a common structural unit has been synthesized.

A General Synthetic Route to Fused Furans. Total Synthesis of (+)-Pallescensin A

A general and facile synthetic route to fused furans has been developed.The key step of the transformation involves the intramolecular dipolar cycloaddition reaction of the nitrile oxides, 2 and 2', which were generated in situ from the correspondin