1492-52-0

Basic information

• Product Name: Z-SER(TOS)-OME
• Synonyms: N^a-Benzyloxycarbonyl-O-(p-toluenesulfonyl)-L-serine Methyl ester, 98%;Methyl (S)-2-[(benzyloxycarbonyl)amino]-3-(p-toluenesulfonyloxy)propanoate;O-[(4-Methylphenyl)sulfonyl]-N-[(phenylmethoxy)carbonyl]-L-serine methyl ester;L-Serine,O-[(4-Methylphenyl)sulfonyl]-N-[(phenylMethoxy)carbonyl]-, Methyl ester;-OMe;Z-Ser(Tos);Z-L-Ser(Tos)-OMe;Z-O-4-toluenesulfonyl-L-serine methyl ester99%
• CAS NO: 1492-52-0
• Molecular Formula: C₁₉H₂₁NO₇S
• Molecular Weight: 407.44
• Product Categories: Z-Amino Acids and Derivatives;Z-Amino acid series
• Mol File: 1492-52-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 589.3°C at 760 mmHg
• Flash Point: 310.2°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 7.23E-14mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-SER(TOS)-OME(CAS DataBase Reference)
• NIST Chemistry Reference: Z-SER(TOS)-OME(1492-52-0)
• EPA Substance Registry System: Z-SER(TOS)-OME(1492-52-0)

Safety Data

• Hazardous Substances Data: 1492-52-0(Hazardous Substances Data)

Usage

General Description

Z-SER(TOS)-OME is a chemical compound that consists of a serine amino acid attached to a tosyl group, which is often used as a protecting group in organic synthesis. The tosyl group provides stability and protection to the serine amino acid during chemical reactions, allowing for selective manipulation of the molecule. Z-SER(TOS)-OME is commonly used in peptide synthesis and other organic chemistry applications to control the reactivity and specificity of the serine amino acid. Additionally, Z-SER(TOS)-OME is also used as a building block in the creation of complex molecules and pharmaceutical drugs. Overall, Z-SER(TOS)-OME plays an important role in the development and production of various chemical and pharmaceutical products.

InChI:InChI=1/C19H21NO7S/c1-14-8-10-16(11-9-14)28(23,24)27-13-17(18(21)25-2)20-19(22)26-12-15-6-4-3-5-7-15/h3-11,17H,12-13H2,1-2H3,(H,20,22)/t17-/m0/s1

Upstream product

• 1676-81-9 N-benzyloxycarbonyl-L-serine methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 501-53-1 benzyl chloroformate 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 

Downstream Products

• 56991-25-4 2-Benzyloxycarbonyl-4-benzyloxycarbonylamino-pentanedioic acid 1-benzyl ester 5-methyl ester 
• 62107-38-4 methyl (R)-(+)-2-(benzyloxycarbonylamino)-3-chloropropionoate 
• 62965-15-5 methyl 2-(R)-(benzyloxycarbonylamino)-3-bromomethylpropionate 
• 56877-38-4 methyl N-((benzyloxy)carbonyl)-3-iodo-L-alaninate 
• 119154-85-7 4-benzyloxycarbonylamino-2-methylpyrazolidin-3-one 
• 39692-63-2 2-benzyloxycarbonylamino-acrylic acid 
• 153277-33-9 N-benzyloxycarbonyl-S-phenyl-L-cysteine methyl ester 
• 56877-40-8 Z-γ,γ,-di-tert-butyl-D,L-carboxyglutamic acid methyl ester 
• 21149-17-7 methyl 2-(benzyloxycarbonylamino)acrylate 
• 56926-93-3 2-[2-Benzyloxycarbonylamino-2-(ethoxycarbonylmethyl-carbamoyl)-ethyl]-malonic acid di-tert-butyl ester 
• 56877-43-1 Z-DL-Gla(OtBu)2-OH 
• 56877-43-1 N-(benzyloxycarbonyl)-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid 
• 60686-50-2 N-(benzyloxycarbonyl)-γ,γ-di-tert-butyl-L-γ-carboxyglutamic acid 
• 397243-75-3 (R)-2-Benzyloxycarbonylamino-3-(4-phenoxy-benzenesulfonyl)-propionic acid methyl ester 

Relevant articles and documents

Utility of tetrathiomolybdate and tetraselenotungstate: Efficient synthesis of cystine, selenocystine, and their higher homologues

Efficient synthesis of cystine, selenocystine, and their higher homologues like homo and bishomo amino acid derivatives from natural amino acid derivatives using tetrathiomolybdate and tetraselenotungstate reagents under mild and neutral conditions is reported. The generality of the reaction has been studied by capping various groups to amino and carboxyl components of canonical amino acids.

α-Amino-β-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1

A series of α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-13 and selectivity versus MMP-1. Various substituents were employed on the α-amino group (P1 position), as well as different groups attached to the su