153277-33-9Relevant articles and documents
Process for S-Aryl cysteine
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Page 13, (2008/06/13)
The present invention provides methods for preparing S-aryl cysteines in enantiomeric excess of greater than about 96%. Specifically, the present invention provides enantioselective methods for preparing S-aryl cysteines starting from cystine, cysteine or
Process for producing of cysteine derivatives
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, (2008/06/13)
PCT No. PCT/JP98/00101 Sec. 371 Date Apr. 22, 1999 Sec. 102(e) Date Apr. 22, 1999 PCT Filed Jan. 14, 1998 PCT Pub. No. WO98/30538 PCT Pub. Date Jul. 16, 1998This invention relates to a method comprising reacting an amino acid derivative of the following general formula (I); (wherein R1 represents an amino-protective group; R0 represents hydrogen or, taken together with R1, represents an amino-protecting group; R2 represents a carboxy-protecting group; X represents a leaving group) with a thiol compound of the following general formula (II):R3SH(II)(wherein R3 represents an alkyl group of 1 to 7 carbon atoms, an aryl group of 6 to 10 carbon atoms, or an aralkyl group of 7 to 10 carbon atoms) to give a cysteine derivative of the following general formula (III): (wherein R0, R1, R2, and R3 are as defined above), wherein the reaction is conducted in the presence of a base and water in an organic reaction solvent.
A total synthesis of (-)-slaframine from (+)-cis-(2R,3S)-3-hydroxyproline
Knight,Sibley
, p. 6607 - 6610 (2007/10/02)
A total synthesis of the naturally occurring indolizidine (-)-Slaframine 4 has been achieved, starting from the cis-3-hydroxyproline derivative 1, in which a key step is a Julia olefination reaction using the dianion derived from the β-aminosulfone 5.