149221-40-9

Basic information

• Product Name: 2-Cyclopenten-1-one, 3-[(phenylmethyl)amino]-
• CAS NO: 149221-40-9
• Molecular Formula: C12H13NO
• Molecular Weight: 187.241
• Mol File: 149221-40-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-Cyclopenten-1-one, 3-[(phenylmethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopenten-1-one, 3-[(phenylmethyl)amino]-(149221-40-9)
• EPA Substance Registry System: 2-Cyclopenten-1-one, 3-[(phenylmethyl)amino]-(149221-40-9)

Safety Data

• Hazardous Substances Data: 149221-40-9(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 205999-79-7 3-oxocyclopent-1-en-1-yl 4-methylbenzenesulfonate 
• 930-30-3 cyclopent-2-enone 
• 622-79-7 benzyl azide 
• 5870-62-2 3-hydroxy-2-cyclopenten-1-one 
• 3859-41-4 1,3-cyclopentadione 

Downstream Products

• 28566-12-3 3-amino-cyclopent-2-en-1-one 
• 1402907-02-1 1-benzyl-1,2,6,7-tetrahydro-2-methyl-2-(4-methylpent-3-enyl)-5H-cyclopenta[b]pyridin-5-one 
• 1402907-01-0 1-benzyl-1,2,6,7-tetrahydro-2,2-dimethyl-5H-cyclopenta[b]pyridin-5-one 
• 183674-21-7 N-benzyl-N-(3-oxocyclopent-1-enyl)pent-4-enamide 

Relevant articles and documents

Lewis Acid-Mediated Reactions of Alkyl Azides with α,β- Unsaturated Ketones

(Matrix presented) Alkyl azides react with saturated ketones upon treatment with Lewis acids to afford ring-expansion products through the azido-Schmidt reaction, but this reaction does not proceed when α,β-unsaturated ketones are used. In this study, alk

A four-component domino reaction: An eco-compatible and highly efficient construction of 1,8-naphthyridine derivatives, their in silico molecular docking, drug likeness, ADME, and toxicity studies

A multicomponent domino reaction of enaminone, malononitrile, and o-phthalaldehyde has been established, providing direct access to novel highly functionalized pentacyclic cyclopenta [b] indeno [1, 2, 3-de] [1,8] naphthyridine derivatives. The simplicity of execution, readily available substrates, high yields, excellent functional group tolerance, scalability, and good scores of environmental parameters make this synthetic strategy more sustainable and worthy of further attention. This one-pot transformation, which involved multiple steps and did not require the use of a catalyst, constructed four new C-C bonds, two new C-N bonds, and three new rings, with efficient use of all reactants. Furthermore, we performed in silico molecular docking analysis for prediction of anticancer (against human topoisomerase IIβ protein) and antimicrobial (against E.coli. DNA gyrase B protein) activities. Drug likeness and ADMET studies were also predicted. Overall investigation indicates that compound 6i may serve as a candidate that could be developed as potential anticancer and antimicrobial agent among all.

Cu catalyzed cross-dehydrogenative coupling reaction for the synthesis of 3-hydroxy-2-pyrrolidinones

A new convenient strategy for the synthesis of 3-hydroxy-2-pyrrolidinone derivatives featuring regioselective C–C coupling has been developed. This is a Cu (II) catalyzed cross dehydrogenative coupling (CDC) involving enamino-ketones of benzyl amines and di-alkyl acetylenedicarboxylate, followed by cyclization by primary amines. TBHP (tert-butyl hydroperoxide) has been used as the oxidant to promote the coupling protocol. This synthetic route principally demonstrates the scope of CDC reaction and also applicable to gram-scale synthesis.