149228-58-0

Upstream product

• 136159-65-4 (R)-4-benzyl-3-(3-phenyl-propionyl)-oxazolidin-2-one 
• 149228-50-2 (R)-4-Benzyl-3-((E)-(2R,3S)-2-benzyl-6-cyclohexyl-3-hydroxy-hex-4-enoyl)-oxazolidin-2-one 
• 4404-92-6 (E)-4-cyclohexyl-2-buten-1-al 
• 149228-51-3 (E)-(3R,6R)-6-Benzyl-7-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-cyclohexylmethyl-7-oxo-hept-4-enoic acid ethyl ester 

Relevant academic research and scientific papers

A concise and enantioselective synthesis of novel HIV-1 protease transition state mimics

Novel HIV-1 protease inhibitors have been prepared in an enantioselective manner via an Evans asymmetric aldol, Claisen rearrangement and iodolactonization. X-ray crystallographic analysis was used to confirm the absolute configuration of the newly created stereogenic centers.