149242-85-3Relevant academic research and scientific papers
Dihydroxylation Studies of Isoquinolinones: Synthesis of the EF-Ring of Lysolipin i
Heinemann, Maximilian J. B.,Voigt, Thomas,Menche, Dirk
, p. 465 - 474 (2021/10/25)
Inspired by the potent polycyclic xanthone antibiotic lysolipin I, a general study on asymmetric dihydroxylation reactions of variously substituted isoquinolinones was performed. Different isoquinolinones were efficiently prepared, either by a Pomeranz-Fritsch type condensation or a Curtius rearrangement. Under a broad variety of conventional oxygenation procedures, they proved very unreactive. However, either by suitable substitution of the appending aromatic ring or more forcing conditions a dihydroxylation could finally be performed, which allowed the synthesis of the EF-ring of lysolipin I.
NUCLEAR RECEPTOR BINDING AGENTS
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Page/Page column 50-51, (2008/12/07)
The present invention relates to a novel class of nuclear receptor binding agents (NRBAs). The NRBAs are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as pr
