149246-82-2

Basic information

• Product Name: 5-(2-Methoxyphenyl)-2H-pyrazol-3-ylamine
• Synonyms: 5-Amino-3-(2-methoxyphenyl)-1H-pyrazole;3-(2-Methoxyphenyl)-1H-pyrazol-5-amine;3-(2-Methoxyphenyl)pyrazol-5-aMine
• CAS NO: 149246-82-2
• Molecular Formula: C₁₀H₁₁N₃O
• Molecular Weight: 189.21
• Product Categories: Amines and Anilines;Heterocycles
• Mol File: 149246-82-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 417 °C at 760 mmHg
• Flash Point: 206 °C
• Appearance: /
• Density: 1.24 g/cm³
• CAS DataBase Reference: 5-(2-Methoxyphenyl)-2H-pyrazol-3-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-Methoxyphenyl)-2H-pyrazol-3-ylamine(149246-82-2)
• EPA Substance Registry System: 5-(2-Methoxyphenyl)-2H-pyrazol-3-ylamine(149246-82-2)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 149246-82-2(Hazardous Substances Data)

Usage

General Description

5-(2-Methoxyphenyl)-2H-pyrazol-3-ylamine is a chemical compound that falls under the category of organic substances, specifically pyrazoles. It is made up of three components: a pyrazole moiety (2H-pyrazol-3-ylamine), a methoxyphenyl group, and an amine group. The detailed physical properties or uses of this specific compound are not well-documented in scientific literature, suggesting that it may not be extensively studied or commercialized. Like other organic compounds, its structure and properties can be analyzed using a variety of techniques including nuclear magnetic resonance, infrared spectroscopy, and mass spectrometry.

Upstream product

• 35276-83-6 3-(2-methoxyphenyl)-3-oxopropanenitrile 
• 7335-26-4 ethyl 2-methoxybenzoate 
• 606-45-1 2-methoxybenzoic acid methyl ester 

Downstream Products

• 1374979-30-2 C₁₅H₁₈BrN₃O₂ 
• 1247949-28-5 C₁₂H₁₄N₄O 
• 1247949-31-0 C₁₂H₁₂N₄O 
• 1247949-30-9 C₁₉H₂₀N₄O₄S 
• 1247949-29-6 C₁₂H₁₄N₄O₂ 
• 1217087-05-2 C₂₅H₂₅N₃O₃ 

Relevant articles and documents

Synthesis and biological evaluation of 7-(aminoalkyl)pyrazolo[1,5-a]pyrimidine derivatives as cathepsin K inhibitors

A series of novel 7-aminoalkyl substituted pyrazolo[1,5-a]pyrimidine derivatives were synthesized and tested for inhibition of cathepsin K. The synthetic methodology comprises cyclization of 5-aminopyrazoles with N-Boc-α-amino acid-derived ynones followed by transformation of the ester and the Boc-amino functions. It allows for easy diversification of the pyrazolo[1,5-a]pyrimidine scaffold at various positions. Molecular docking studies with pyrazolo[1,5-a]pyrimidine derivatives were also performed to elucidate the binding mode in the active site of cathepsin K. The synthesized compounds exhibited moderate inhibition activity (Ki ≥ 77 μM).

Pyrazolotriazines as inhibitors of nucleases

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

A convenient synthesis of 3- and 5-amino-1 H -pyrazoles via 3(5)-amino-4-(ethylsulfi nyl)-1 H -pyrazole desulfi nylation

Syntheses of 5-amino-3-aryl- and 3-amino-5-aryl-1 H -pyrazoles from β -bromo- α -(ethylsulfanyl)cinnamonitrile are described. The β -bromo- α -(ethylsulfanyl)cinnamonitriles were oxidized with H2O 2 to the corresponding β -bromo- α -