1492902-42-7

Basic information

• Product Name: N-(2-bromo-4-methylphenyl)-2-(4-(4-tert-butylphenyl)-5-isopropyl-4H-1,2,4-triazol-3-ylthio)acetamide
• Synonyms: N-(2-bromo-4-methylphenyl)-2-(4-(4-tert-butylphenyl)-5-isopropyl-4H-1,2,4-triazol-3-ylthio)acetamide
• CAS NO: 1492902-42-7
• Molecular Weight: 501.49
• Mol File: 1492902-42-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-bromo-4-methylphenyl)-2-(4-(4-tert-butylphenyl)-5-isopropyl-4H-1,2,4-triazol-3-ylthio)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-bromo-4-methylphenyl)-2-(4-(4-tert-butylphenyl)-5-isopropyl-4H-1,2,4-triazol-3-ylthio)acetamide(1492902-42-7)
• EPA Substance Registry System: N-(2-bromo-4-methylphenyl)-2-(4-(4-tert-butylphenyl)-5-isopropyl-4H-1,2,4-triazol-3-ylthio)acetamide(1492902-42-7)

Safety Data

• Hazardous Substances Data: 1492902-42-7(Hazardous Substances Data)

Upstream product

• 1492902-52-9 C₁₅H₂₃N₃OS 
• 19241-24-8 4-(tert-butylbenzyl)isothiocyanate 
• 583-68-6 2-bromo-p-toluidine 
• 90560-54-6 PCM-0102196 
• 1038308-06-3 C₁₅H₂₁N₃S 

Relevant articles and documents

Arylazolylthioacetanilide. Part 11: Design, synthesis and biological evaluation of 1,2,4-triazole thioacetanilide derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

A series of novel 1,2,4-triazole thioacetanilide derivatives has been designed, synthesized and evaluated for their anti-HIV activities in MT-4 cells. Half of these compounds showed moderate to potent activities against wild-type HIV-1 with an EC50 ranging from 38.0 μM to 4.08 μM. Among them, 2-(4-(2-fluorobenzyl)-5-isopropyl-4H-1,2,4-triazol-3-ylthio)-N-(2-nitrophenyl) acetamide 7d was identified as the most promising compound (EC50 = 4.26 μM, SI = 49). However, no compound was active against HIV-2. The preliminary structure-activity relationships among the newly synthesized congeners are discussed.