149298-89-5Relevant articles and documents
The first total synthesis of tetronasin (M139603)
Hori, Kozo,Kazuno, Hideki,Nomura, Keiichi,Yoshii, Eiichi
, p. 2183 - 2186 (2007/10/02)
Total synthesis tetronasin (1), a tetronic acid polyether ionophore antibiotic, is reported in which the γ-unsubstituted α-acyltetronic acid structure is constructed by cyclization of a β-keto ester derivative 18 derived from tricyclic aldehyde intermediate 17 by reaction with methyl (diazoacetoxy)acetate in the presence of zirconium tetrachloride.