1493-87-4Relevant academic research and scientific papers
A general and efficient route for the preparation of phenyl-substituted vinyl fluorides
Tsai, Hou-Jen,Lin, Keh-Wen,Ting, Tzu-Hao,Burton, Donald J.
, p. 2231 - 2239 (1999)
α-fluorobenzyl phosphonate (EtO)2P(O)CFHPh (2) prepared from diethyl α-hydroxyphosphonate (EtO)2P(O)CH(OH)Ph (1) and diethylaminosulfur trifluoride (DAST), reacts with bases such as butyllithium, tert- butyllithium, lithium bis(trime
Palladium/copper (I) halide-cocatalyzed stereospecific coupling of 1- fluorovinylstannanes with aryl iodides and acyl chlorides
Chen, Chen,Wilcoxen, Keith,Kim, Kyung-Il,McCarthy, James R.
, p. 7677 - 7680 (1997)
Cross-coupling of 1-fluorovinylstannanes with aryl iodides or acyl chlorides, cocatalyzed by palladium and copper (I) iodide proceeded under mild conditions to give substituted fluoro olefins and α-fluoro-α,β- unsaturated ketones, respectively, in good yi
Coupling of 2-substituted 1-fluorovinylstannanes with organic halides catalyzed by palladium(0)/copper(I) iodide. A mild and stereospecific method to monofluoroolefins
Chen,Wilcoxen,Zhu,Kim,McCarthy
, p. 3476 - 3482 (1999)
The palladium-catalyzed cross-coupling reactions of (E)- or (Z)-1- fluorovinylstannanes with aryl iodides and vinyl iodides provide good yields of stereoisomerically pure substituted fluoroolefins with retention of the double bond geometry. The reaction t
Synthesis of phenyl substituted fluoro-olefins
Tsai, Hou-Jen
, p. 629 - 632 (1996)
The anion derived from diethyl α-fluorobenzyl phosphonate (EtO)2P(O)-CFHPh (2) and lithium diisopropylamide in THF underwent the reaction with aldehydes and ketones to afford a moderate to good yields of phenyl substituted fluoro-olefins RR'C =
Copper(I)-Mediated Borofluorination of Alkynes
Jordan, Abraham J.,Thompson, Percie K.,Sadighi, Joseph P.
, p. 5242 - 5246 (2018)
The electrophilic fluorination of N-heterocyclic carbene (NHC) copper(I) vinyls results in fluoroalkene formation. Alkynes can be converted to cis-(β-fluorovinyl)boronates by a reaction with an (NHC)copper(I) boryl generated in situ, followed by N-fluorobenzenesulfonimide (NFSI). This sequence gives rise to anti-Markovnikov fluorination products from terminal alkynes. Oxidation of a cis-(β-fluorovinyl)trifluoroboronate yields an α-fluoroketone, whereas a palladium-catalyzed Suzuki-Miyaura coupling yields a tetrasubstituted monofluoroalkene.
