149324-24-3

Basic information

• Product Name: 2-isopropyl-1,3,4-oxadiazole
• Synonyms: 2-isopropyl-1,3,4-oxadiazole;2-(1-Methylethyl)-1,3,4-oxadiazole
• CAS NO: 149324-24-3
• Molecular Formula: C5H8N2O
• Molecular Weight: 112.12982
• Mol File: 149324-24-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 155℃
• Flash Point: 46℃
• Appearance: /
• Density: 1.031
• Vapor Pressure: 4.019mmHg at 25°C
• Refractive Index: 1.445
• CAS DataBase Reference: 2-isopropyl-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-isopropyl-1,3,4-oxadiazole(149324-24-3)
• EPA Substance Registry System: 2-isopropyl-1,3,4-oxadiazole(149324-24-3)

Safety Data

• Hazardous Substances Data: 149324-24-3(Hazardous Substances Data)

Usage

General Description

2-isopropyl-1,3,4-oxadiazole is a heterocyclic compound with the molecular formula C5H8N2O. It is a five-membered ring with two nitrogen atoms and one oxygen atom. This chemical is used as a precursor in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in the production of fragrances and flavorings. 2-isopropyl-1,3,4-oxadiazole has been studied for its potential pharmacological properties, including antimicrobial and antitumor activities. It is important to handle this chemical with care as it may pose health hazards if not used properly.

InChI:InChI=1/C5H8N2O/c1-4(2)5-7-6-3-8-5/h3-4H,1-2H3

Upstream product

• 3619-17-8 isobutyric acid hydrazide 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 1026531-06-5 (2-(4-Fluoro-phenyl)-1-{[(S)-1-(5-isopropyl-[1,3,4]oxadiazole-2-carbonyl)-2-methyl-propylcarbamoyl]-methyl}-6-oxo-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester 
• 1026312-25-3 [2-(4-Fluoro-phenyl)-1-({(S)-1-[hydroxy-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-methyl]-2-methyl-propylcarbamoyl}-methyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester 

Relevant articles and documents

COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME

The present specification provides a compound represented by chemical formula 1 and an organic light emitting device including the same. The compound may improve lifespan characteristics of the organic light emitting device.

Development of orally active nonpeptidic inhibitors of human neutrophil elastase

5-Amino-2-phenylpyrimidin-6-ones, some of their desamino derivatives, and miscellaneous derivatives were synthesized and biologically evaluated on both in vitro activity and oral activity in an acute hemorrhagic assay. These compounds contained an α-keto-1,3,4-oxadiazole moiety to bind covalently to the Ser-195 hydroxy group of human neutrophil elastase (HNE). Among those tested, compounds 11a-c,e,i-l(F), 11d,e,k(H), 21d,e,k(F), and 21d,e(H) showed a good oral profile. RS-Mixture 3(H) was selected for clinical evaluation based on its oral potency, duration of action, enzyme selectivity, safety profile, and ease of synthesis. Structure -activity relationships (SARs) are discussed.