1493774-30-3Relevant academic research and scientific papers
Deconstructive di-functionalization of unstrained, benzo cyclic amines by C-N bond cleavage using a recyclable tungsten catalyst
Zhang, Yujing,Sun, Shuai,Su, Yijin,Zhao, Jian,Li, Yong-Hong,Han, Bo,Shi, Feng
supporting information, p. 4970 - 4974 (2019/05/29)
With H2WO4 as the catalyst and H2O2 as the oxidant, we herein report a deconstructive difunctionalization of the C-N bond in unstrained, benzo cyclic amines to generate an ester group and nitro group simultaneously. The preliminary mechanistic studies suggested that the corresponding hydroxamic acid is the key intermediate for this transformation. Importantly, with the utilization of this transformation, we achieved an interesting approach for the ring contraction of quinoline to indole, an example of scaffold hopping in a hetero-aromatic system.
Reductive cyclizations of nitroarenes to hydroxamic acids by visible light photoredox catalysis
Cismesia, Megan A.,Ischay, Michael A.,Yoon, Tehshik P.
supporting information, p. 2699 - 2705 (2013/10/21)
We have developed a photocatalytic reduction of nitroarenes as an efficient, chemoselective route to biologically important N-phenyl hydroxamic acid scaffolds. Optimal conditions call for 2.5 mol% of a ruthenium photocatalyst, visible light irradiation, and a dihydropyridine terminal reductant. Because of the mild nature of the visible light activation, functional groups that might be sensitive to other non-photochemical reduction methods are easily tolerated. Georg Thieme Verlag Stuttgart New York.
