149484-76-4Relevant academic research and scientific papers
Synthesis and antitumor evaluation of some new substituted amidino-benzimidazolyl-furyl-phenyl-acrylates and naphtho[2,1-b]furan- carboxylates
Hranjec,Grdisa,Pavelic,Boykin,Karminski-Zamola
, p. 1319 - 1324 (2003)
The multistep synthesis of a series of substituted amidino-benzimidazolyl- furyl-phenyl-acrylic acid's esters and substituted amidino-benzimidazolyl- naphtho[2,1-b]furan-carboxylic acid's esters is described starting from corresponding 3-(2-furyl)-2-phenyl-acrylic acids. The new compounds were tested on the cytostatic activities against malignant cell lines: pancreatic carcinoma (MiaPaCa2), breast carcinoma (MCF7), cervical carcinoma (HeLa), laryngeal carcinoma (Hep2), colon carcinoma (HT 29), melanoma (HBL), and human fibroblasts cell line (WI38). All compounds inhibited the proliferation of tumor cell lines. Inhibitory effect of examined compounds depended on concentration, but without significant difference among the type of tumor cells. The compounds 2 and 5 exerted very low inhibitory effect on the growth of human fibroblasts. Unsubstituted derivative 8 has not inhibited any tested cell lines.
Synthesis, photochemical synthesis, DNA binding and antitumor evaluation of novel cyano- and amidino-substituted derivatives of naphtho-furans, naphtho-thiophenes, thieno-benzofurans, benzo-dithiophenes and their acyclic precursors
Starcevic, Kristina,Kralj, Marijeta,Piantanida, Ivo,Suman, Lidija,Pavelic, Kresimir,Karminski-Zamola, Grace
, p. 925 - 939 (2007/10/03)
As a part of the research on the improvement of an alternative to conventional photodynamic therapy by light-induced formation of intercalators, we synthesized a series of novel heterocyclic compounds and their acyclic precursors. We now report details ab
