149488-96-0Relevant articles and documents
Microwave-assisted rapid synthesis of spirooxindole-pyrrolizidine analogues and their activity as anti-amyloidogenic agents
de Silva, Nilamuni H.,Pyreddy, Suneela,Blanch, Ewan W.,Hügel, Helmut M.,Maniam, Subashani
, (2021)
A library of Sox-pyrrolizidines was rapidly prepared by microwave-assisted, one-pot, three-component, 1,3-dipolar cycloaddition of azomethine ylides from l-proline and isatin, with various β-nitrostyrenes. Nitro-Sox compounds, 4b, 4d and 4e inhibit HEWL amyloid fibril formation by ThT studies with percentages of fluorescence intensity of 55.4, 42.9 and 40.3%, respectively. Further studies with MTT assay, Raman spectroscopy, TEM and molecular docking supported these promising candidates for activity against amyloid misfolding, a phenomenon leading to Alzheimer's disease pathology.
Pd-catalyzed cross-coupling of carboxylic acids with nitroethane via combination of decarboxylation and dehydrogenation
Zhang, Min,Zhou, Jun,Kan, Jian,Wang, Min,Su, Weiping,Hong, Maochun
supporting information; experimental part, p. 5455 - 5457 (2010/10/04)
An unexpected coupling reaction of arene carboxylic acid with nitroethane via a combination of decarboxylation and dehydrogenation is described. The method provides exclusively (E)-β-nitrostyrenes. The Royal Society of Chemistry 2010.
