149489-04-3

Usage

Uses

Used in Pesticide Industry:
CARBAMIC ACID, (3-BROMO-2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER is used as a pesticide to control a wide range of pests. It is effective in managing various types of insects and other organisms that can cause damage to crops and other plants.
Used in Herbicide Industry:
In the herbicide industry, CARBAMIC ACID, (3-BROMO-2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER is utilized to control weeds that compete with crops for resources. Its ability to inhibit essential enzymes in weeds makes it a valuable tool in ensuring the health and productivity of agricultural fields.

Upstream product

• 626-55-1 3-Bromopyridine 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 13534-99-1 2-Amino-3-bromopyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 109-72-8 n-butyllithium 
• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 
• 106-93-4 ethylene dibromide 
• 39856-58-1 3-amino-2-bromopyridine 

Downstream Products

• 13534-99-1 2-Amino-3-bromopyridine 
• 1288990-82-8 8-bromo-3-methylimidazo[1,2-a]pyridine 

Relevant academic research and scientific papers

Development of a Novel Process for the Kilogram-Scale Synthesis of Spiro[1 H-pyrido[2,3- d][1,3]oxazine-4,4′-piperidine]-2-one

Spiro[1H-pyrido[2,3-d][1,3]oxazine-4,4′-piperidine]-2-one (3) is a key building block in many biologically active compounds. The synthesis of this compound, as reported in the literature, is low-yielding. We have discovered and developed a robust, high-yielding process to generate 3 as a bis-HCl salt using alternative starting materials and reaction conditions. The developed process was successfully demonstrated on a kilogram scale. A two-batch kilo lab campaign generated the bis-HCl salt of 3 in >99 HPLC area percent purity and 77% overall yield.

A multifunctional reagent designed for the site-selective amination of pyridines

We report the development of a multifunctional reagent for the direct conversion of pyridines to Boc-protected 2-aminopyridines with exquisite site selectivity and chemoselectivity. The novel reagent was prepared on 200-g scale in a single step, reacts in the title reaction under mild conditions without precautions toward air or moisture, and is tolerant of nearly all common functionality. Experimental and in situ spectroscopic monitoring techniques provide detailed insights and unexpected findings for the unique reaction mechanism.

Hydroarylation of Arenes via Reductive Radical-Polar Crossover

A photocatalytic system for the dearomative hydroarylation of benzene derivatives has been developed. Using a combination of an organic photoredox catalyst and an amine reductant, this process operates through a reductive radical-polar crossover mechanism where aryl halide reduction triggers a regioselective radical cyclization event, followed by anion formation and quenching to produce a range of complex spirocyclic cyclohexadienes. This light-driven protocol functions at room temperature in a green solvent system (aq. MeCN) without the need for precious metal-based catalysts or reagents or the generation of stoichiometric metal byproducts.

NEW SUBSTITUTED AZAINDOLINE DERIVATIVES AS NIK INHIBITORS

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

Method for inhibition of HIV related viruses

Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.