149490-61-9

Basic information

• Product Name: N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine
• Synonyms: (2S)-2-(butane-1-sulfonaMido)-3-{4-[4-(pyridin-4-yl)butoxy]phenyl}propanoic acid;(S)-2-(ButylsulfonaMido)-3-(4-(4-(pyridin-4-yl)butoxy)phenyl)propanoic acid;-3-(4-(4-(pyridin-4-yl);N-BUTYLSULFONYL-O-(4-(4-PYRIDINYL)BUTYL)-L-TYROSINE;Tirofiban Hydrochloride Impurity B;N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosi;Tirofiban Impurity C;N-Butanesulfonyl-O-[4-(4-pyridinyl)-butyl]-(S)-tyrosine
• CAS NO: 149490-61-9
• Molecular Formula: C₂₂H₃₀N₂O₅S
• Molecular Weight: 434.55
• Product Categories: Aromatics;Inhibitors
• Mol File: 149490-61-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 135-137℃
• Boiling Point: 648.228 °C at 760 mmHg
• Flash Point: 345.836 °C
• Appearance: /
• Density: 1.217 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: 2-8°C
• PKA: 3.37±0.10(Predicted)
• CAS DataBase Reference: N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine(149490-61-9)
• EPA Substance Registry System: N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine(149490-61-9)

Safety Data

• Hazardous Substances Data: 149490-61-9(Hazardous Substances Data)

Usage

Chemical Properties

Pale Beige Solid

Uses

Tirofiban intermediate.

InChI:InChI=1/C22H30N2O5S/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18/h7-14,21,24H,2-6,15-17H2,1H3,(H,25,26)/t21-/m0/s1

Upstream product

• 149463-65-0 4-(4-pyridinyl)butyl chloride hydrochloride 
• 108-89-4 picoline 
• 5264-17-5 4-(pyridin-4-yl)-1-chlorobutane 
• 1352839-95-2 N-n-butylsulfonyl-L-tyrosine ethyl ester 
• 949-67-7 L-tyrosine ethyl ester 
• 102878-73-9 γ-(pyridin-4-yl)butyric acid 
• 100-43-6 4-vinylpyridine 
• 5264-15-3 4-(4-pyridinyl)butan-1-ol 

Downstream Products

• 144494-65-5 tirofiban hydrochloride 
• 144494-65-5 tirofiban 

Relevant articles and documents

Synthesis method of tirofiban hydrochloride intermediate III (by machine translation)

The invention belongs to the field, of medicine synthesis, and particularly relates to a synthesis method III of tirofiban hydrochloride intermediate. by, reduction of an intermediate I under the action of a sodium borohydride reducing system to obtain intermediate II, intermediate II under Lewis acid chloride in the presence. SOCl2 Reaction conditions of, process are mild III, and N - process operation is simple, the reaction conditions of the reaction yield, product are improved, the product purity is high, and the reaction yield is increased by, times without being subjected to column purification, to improve the clinical medication safety, of the injection using, the standard crude drug product of the pharmacopoeia standard, and is suitable, for industrial production. (by machine translation)

Tirofiban hydrochloride process for preparing

The invention belongs to the field of medicine and chemical industry. According to the present invention, the tirofiban hydrochloride prepared through substitution, condensation, reduction, salification and other reactions has characteristics of high yield, good quality and good stability, and the preparation process of the present invention provides a synthesis process suitable for the practical industrial mass production.