102878-73-9

Basic information

• Product Name: 4-PYRIDIN-4-YL-BUTYRIC ACID
• Synonyms: ASINEX-REAG BAS 10145970;4-PYRIDIN-4-YL-BUTYRIC ACID;4-PYRIDIN-4-YLBUTANOIC ACID;4-Pyridinebutanoic acid;Tirofiban hydrochloride Impurity 30
• CAS NO: 102878-73-9
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Mol File: 102878-73-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 325.9±17.0 °C(Predicted)
• Appearance: /
• Density: 1.154±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.60±0.10(Predicted)
• CAS DataBase Reference: 4-PYRIDIN-4-YL-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIDIN-4-YL-BUTYRIC ACID(102878-73-9)
• EPA Substance Registry System: 4-PYRIDIN-4-YL-BUTYRIC ACID(102878-73-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 102878-73-9(Hazardous Substances Data)

Usage

General Description

4-Pyridin-4-yl-butyric acid, also known as P4B, is a chemical compound with the molecular formula C9H11NO2. It is a derivative of pyridine and has a butyric acid moiety attached to the nitrogen atom of the pyridine ring. P4B is a versatile compound with various applications in the pharmaceutical and agrochemical industries. It is used as a building block in the synthesis of pharmaceutical drugs, agrochemicals, and functional materials. Additionally, P4B has been studied for its potential therapeutic effects on various diseases, including cancer, diabetes, and neurodegenerative disorders. Its unique chemical structure and pharmacological properties make 4-Pyridin-4-yl-butyric acid a valuable compound for research and development in the fields of medicine and agriculture.

Upstream product

• 92501-98-9 ethyl 2-ethoxycarbonyl-4-(pyrid-4-yl)-butanoate 
• 100-43-6 4-vinylpyridine 
• 105-53-3 diethyl malonate 
• 5264-02-8 3-(4-pyridyl)-1-chloropropane 
• 2629-72-3 4-(3-Hydroxypropyl)pyridine 
• 84200-09-9 4-(3-cyanopropyl)pyridine 

Downstream Products

• 84200-09-9 4-(3-cyanopropyl)pyridine 
• 5264-15-3 4-(4-pyridinyl)butan-1-ol 
• 144494-65-5 tirofiban hydrochloride 
• 149490-61-9 N-(n-butanesulfonyl)-O-(4-(4-pyridinyl)-butyl)-(S)-tyrosine 
• 5264-17-5 4-(pyridin-4-yl)-1-chlorobutane 
• 1026564-84-0 4-[3-({[(S)-2-Benzyloxycarbonyl-1-((S)-1-benzyloxycarbonyl-2-cyclohexyl-ethylcarbamoyl)-ethylcarbamoyl]-methyl}-ethyl-carbamoyl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1026853-21-3 4-[3-({[(S)-2-Benzyloxycarbonyl-1-((R)-1-benzyloxycarbonyl-2-cyclohexyl-ethylcarbamoyl)-ethylcarbamoyl]-methyl}-ethyl-carbamoyl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 194933-88-5 4-[3-({[(S)-2-Benzyloxycarbonyl-1-((S)-1-benzyloxycarbonyl-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-methyl}-ethyl-carbamoyl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 169512-83-8 N-[N-[N-(4-(N-BOC-piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine 

Relevant articles and documents

Toward the Control of the Creation of Mixed Monolayers on Glassy Carbon Surfaces by Amine Oxidation

A versatile and simple methodology for the creation of mixed monolayers on glassy carbon (GC) surfaces was developed, using an osmium-bipyridyl complex and anthraquinone as model redox probes. The work consisted in the electrochemical grafting on GC of a mixture of mono-protected diamine linkers in varying ratios which, after attachment to the surface, allowed orthogonal deprotection. After optimisation of the deprotection conditions, it was possible to remove one of the protecting groups selectively, couple a suitable osmium complex and cap the residual free amines. The removal of the second protecting group allowed the coupling of anthraquinone. The characterisation of the resulting surfaces by cyclic voltammetry showed the variation of the surface coverage of the two redox centres in relation to the initial ratio of the linking amine in solution.

Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists

A novel series of Nα-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen (6, 2-[2-(3,3-diphenylpropyl)imidazol-4-yl]ethanamine) was synthesized and evaluated as histamine H1-receptor agonists. The title compounds displayed partial agonism at contractile H1-receptors of guinea pig ileum and were at least equipotent with histamine. Agonist effects of the new derivatives were susceptible to blockade by the H1-receptor antagonist mepyramine (2-100 nM). In the imidazole series, suprahistaprodifen (51, [2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethyl]-[2-(1H-imidazol-4-yl) ethyl]amine, Nα-2-[(1H-imidazol-4-yl)ethyl]histaprodifen) showed the highest H1-receptor agonist potency ever reported in the literature (pEC50 8.26, efficacy Emax 96%). Elongation of the alkyl spacer from ethyl to butyl decreased activity from 3630% (ethyl, 51) to 163% (butyl, 53) of histamine potency. The exchange of the terminal imidazole nucleus for a pyridine ring resulted in compounds with comparably high potency. A decrease in agonist potency and efficacy was observed when the attachment of the alkyl spacer was consecutively changed from the ortho to the meta and the para position, respectively, of the pyridine ring. The pyridine series that contained a butyl chain possessed the highest potency and affinity. Nα-[4-(2-pyridyl)butyl]histaprodifen (56) emerged as a strong partial agonist, being almost equipotent with 51 (pEC50 8.16, E max 89%). Compounds 51 and 56 also showed potent partial agonism at contractile H1 receptors in guinea pig aorta and potently activated H1-receptor-mediated endothelium-dependent relaxation in the rat aorta. Compounds 51-65 displayed low to moderate affinity at H2, H3, and M3 receptors in functional models of guinea pig. Collectively, Nα-imidazolylalkyl- and Nα -pyridylalkyl-substituted histaprodifens represent a novel class of potent H1-receptor agonists. These compounds may be useful to define the (patho)physiological role of the H1-receptor and refine molecular models of H1-receptor activation.