149505-72-6

Basic information

• Product Name: 3'-AMINOBIPHENYL-4-CARBONITRILE
• Synonyms: SALOR-INT L300705-1EA;4-(3-AMINOPHENYL)BENZONITRILE;3'-AMINOBIPHENYL-4-CARBONITRILE;3'-AMINO-[1,1'-BIPHENYL]-4-CARBONITRILE;AKOS BAR-0468;3μ-Amino-[1,1μ-biphenyl]-4-carbonitrile, 3μ-Aminobiphenyl-4-carbonitrile;3-Amino-4'-cyanobiphenyl
• CAS NO: 149505-72-6
• Molecular Formula: C₁₃H₁₀N₂
• Molecular Weight: 194.23
• Mol File: 149505-72-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 119-123 °C(lit.)
• Boiling Point: 414.8°Cat760mmHg
• Flash Point: 204.6°C
• Appearance: /
• Density: 1.18g/cm³
• CAS DataBase Reference: 3'-AMINOBIPHENYL-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-AMINOBIPHENYL-4-CARBONITRILE(149505-72-6)
• EPA Substance Registry System: 3'-AMINOBIPHENYL-4-CARBONITRILE(149505-72-6)

Safety Data

• Hazard Codes: Xi,N
• Statements: 41-50
• Safety Statements: 26-39-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 149505-72-6(Hazardous Substances Data)

Usage

General Description

3'-Aminobiphenyl-4-carbonitrile is a chemical compound with the molecular formula C13H9N3. It is a biphenyl derivative that contains an amino group and a carbonitrile group on adjacent positions of the aromatic ring. 3'-AMINOBIPHENYL-4-CARBONITRILE is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a building block for the production of various dyes and pigments. 3'-Aminobiphenyl-4-carbonitrile is considered to be a hazardous chemical and should be handled and stored with proper safety measures in place to avoid exposure and potential health risks.

Upstream product

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Relevant articles and documents

Design, synthesis, and structure-activity relationship of 7-propanamide benzoxaboroles as potent anticancer agents

Benzoxaboroles, as a novel class of bioactive molecules with unique physicochemical properties, have been shown to possess excellent antimicrobial activities with tavaborole approved in 2014 as an antifungal drug. Although urgently needed, the investigation of benzoxaboroles as anticancer agents has been lacking so far. In this study, we report the design, synthesis, and anticancer structure-activity relationship of a series of 7-propanamide benzoxaboroles. Compounds 103 and 115 showed potent activity against ovarian cancer cells with IC50 values of 33 and 21 nM, respectively. Apoptosis was induced by these compounds and colony formation was effectively inhibited. Furthermore, they also showed excellent efficacy in ovarian tumor xenograft mouse model.

Pd/mannose promoted tandem cross coupling-nitro reduction: Expedient synthesis of aminobiphenyls and aminostilbenes

The dual role of d-mannose as a ligand for Pd catalyzed cross-coupling, and as a hydrogen source for nitro reduction is demonstrated in a modular cross coupling-nitro reduction sequence. The synthetic utility and generality of this green protocol has been illustrated by the synthesis of 20 aminobiphenyl and 10 aminostilbene derivatives in high yields through a one-pot Suzuki coupling-nitro reduction and a Heck coupling-nitro reduction, respectively, starting from halonitroarenes as substrates.

Cyclic imino derivatives and pharmaceutical compositions containing them

The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.