149506-05-8

Usage

Chemical Properties

White powder

InChI:InChI=1/C14H19NO4/c1-14(2,3)19-13(18)15-11-7-4-10(5-8-11)6-9-12(16)17/h4-5,7-8H,6,9H2,1-3H3,(H,15,18)(H,16,17)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 2393-17-1 3-(4-aminophenyl)propionic acid 
• 124-38-9 carbon dioxide 
• 57295-14-4 tert-butyl 4-vinylphenylcarbamate 
• 1520-21-4 4-vinyl benzylamine 
• 590-29-4 potassium formate 
• 619-89-6 p-nitrocinnamic acid 

Downstream Products

• 863666-13-1 [4-(2-benzyloxycarbamoyl-ethyl)-phenyl]-carbamic acid tert-butyl ester 
• 198896-23-0 3-(4-tert-butoxycarbonylaminophenyl)propanol 
• 863666-24-4 N-[4-(2-benzyloxycarbamoyl-ethyl)-phenyl]-4-phenyl-butyramide 
• 863666-17-5 3-(4-amino-phenyl)-N-benzyloxy-propionamide 
• 131818-18-3 p-(N-tert-butoxycarbonyl)aminocinnamic acid 

Relevant academic research and scientific papers

Photoinduced Hydrocarboxylation via Thiol-Catalyzed Delivery of Formate across Activated Alkenes

Herein we disclose a new photochemical process to prepare carboxylic acids from formate salts and alkenes. This redox-neutral hydrocarboxylation proceeds in high yields across diverse functionalized alkene substrates with excellent regioselectivity. This operationally simple procedure can be readily scaled in batch at low photocatalyst loading (0.01% photocatalyst). Furthermore, this new reaction can leverage commercially available formate carbon isotologues to enable the direct synthesis of isotopically labeled carboxylic acids. Mechanistic studies support the working model involving a thiol-catalyzed radical chain process wherein the atoms from formate are delivered across the alkene substrate via CO2?- as a key reactive intermediate.

AMINOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula: (I) where A, B, R1, X1, X2, and W are described herein.

α,β-Dehydrogenation of esters with free O–H and N–H functionalities via allyl-palladium catalysis

A direct and selective method for the α,β-dehydrogenation of esters using palladium catalysis in the presence of free O–H and N–H functionalities is reported herein. Allyl-palladium catalysis allows for preservation of readily oxidizable functionalities s

Direct β-Selective Hydrocarboxylation of Styrenes with CO2 Enabled by Continuous Flow Photoredox Catalysis

The direct β-selective hydrocarboxylation of styrenes under atmospheric pressure of CO2 has been developed using photoredox catalysis in continuous flow. The scope of this methodology was demonstrated with a range of functionalized terminal styrenes, as well as α-substituted and β-substituted styrenes.

Amine compound and process for preparation thereof, liquid crystal aligning, liquid crystal alignment film, the liquid crystal display element (by machine translation)

The present invention relates to an amine compound, a method for preparing same, and a liquid crystal alignment agent, a liquid crystal alignment film, and a liquid crystal display device, having same. A liquid crystal alignment agent having polyamic acid or polyimide prepared using the amine compound of the present invention enables a liquid crystal alignment film and a liquid crystal display device having excellent thermal stability even after forming the liquid crystal alignment film, and expressing high alignment and stability even after an ultraviolet ray irradiation.

Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors

Previously, we developed a strategy to develop a novel class of histone deacetylase (HDAC) inhibitors by tethering short-chain fatty acids with Zn 2+-chelating motifs, which led to N-hydroxy-4-(4-phenylbutyryl-amino) benzamide (HTPB), a hydroxa

Cyclic imino derivatives and pharmaceutical compositions containing them

The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.