149506-54-7Relevant articles and documents
Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton
Miyachi, Hiroyuki,Azuma, Akihiko,Kitamoto, Takuya,Hayashi, Kozue,Kato, Shigeaki,Koga, Masafumi,Sato, Bunzo,Hashimoto, Yuichi
, p. 1483 - 1488 (1997)
Anti-androgenic activity of various phthalimide analogs was evaluated based on inhibition of androgen-induced activation of nuclear androgen receptor (CAT assay) and on growth inhibition of the androgen-dependent clonal cell line SC-3. Some compounds showed very potent androgen-antagonistic activity.