Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton

DOI: 10.1016/S0960-894X(97)00249-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1483 - 1488 (1997)

Update date:2022-07-29

Topics:

Authors:

Miyachi, Hiroyuki

Azuma, Akihiko

Kitamoto, Takuya

Hayashi, Kozue

Kato, Shigeaki

Koga, Masafumi

Sato, Bunzo

Hashimoto, Yuichi

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Article abstract of DOI:10.1016/S0960-894X(97)00249-7

Anti-androgenic activity of various phthalimide analogs was evaluated based on inhibition of androgen-induced activation of nuclear androgen receptor (CAT assay) and on growth inhibition of the androgen-dependent clonal cell line SC-3. Some compounds showed very potent androgen-antagonistic activity.

Full text of DOI:10.1016/S0960-894X(97)00249-7

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