Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton

DOI: 10.1016/S0960-894X(97)00249-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1483 - 1488 (1997)

Update date:2022-07-29

Topics:

Authors:

Miyachi, Hiroyuki

Azuma, Akihiko

Kitamoto, Takuya

Hayashi, Kozue

Kato, Shigeaki

Koga, Masafumi

Sato, Bunzo

Hashimoto, Yuichi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00249-7

Anti-androgenic activity of various phthalimide analogs was evaluated based on inhibition of androgen-induced activation of nuclear androgen receptor (CAT assay) and on growth inhibition of the androgen-dependent clonal cell line SC-3. Some compounds showed very potent androgen-antagonistic activity.

Full text of DOI:10.1016/S0960-894X(97)00249-7

Products guided by the article

Product name:1H-Isoindole-1,3(2H)-dione, 2-[(2,3-dihydro-1H-inden-2-yl)methyl]-

Cas No:149506-54-7

R&D Labs maybe for 149506-54-7

Nantong LiKai Chemical Co.,Ltd

Contact:+86-513-89068669

Address:Jincheng Science Park
Beijing Harmony Chemical Co., Ltd.

Contact:86-010-84956928

Address:Room 207, Jin feng he B building, No 8 Xin Jie Kou Wai Street, Xi Cheng District, Beijing,PRC. 10008
Zhangjiagang Golden Reach Fine Chemical Co.,LTD.

Contact:+86-512-6585 6968

Address:Changfu Road， Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
Shanghai UCHEM Inc.

Contact:+86-21-56338808

Address:799 Dunhuang Road, Putuo
KangZhiYuan Pharmaceutical Company Limited

Contact:(Sabrina)86-20-85273232

Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China

Relevant to this article

Photoisomerization of stilbene dendrimers: The need for a volume-conserving isomerization mechanism

Doi:10.1562/0031-8655(2002)076<0596:POSDTN>2.0.CO;2
(2002)
Doi:10.1002/jps.2600531217
(1964)
Design, synthesis, and biological evaluation of novel non-piperazine analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4- fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines as dopamine transporter inhibitors

Doi:10.1021/jm990161h
(1999)
REACTIONS OF BENZOYLISOTHIOCYANATE WITH ACETOACETANILIDE: SYNTHESIS OF PYRAZOLE, PYRIDINE, PYRIMIDINE, PYRAZOLO<3,4-d>PYRIMIDINE, PYRAZOLO<4,3-d>PYRIMIDINE AND PYRIDO<4,3-d>OXAZINE DERIVATIVES

Doi:10.1135/cccc19930947
(1993)
Synthesis of β-Methyl Alcohols: Influence of Alkyl Chain Length on Diastereoselectivity and New Attractants of Rhynchophorus ferrugineus

Doi:10.1021/acs.jafc.1c01875
(2021)
Annulation reaction of (triphenylmethyl)allene on a cationic metal complex and the reaction mechanism

Doi:10.1021/om00034a032
(1993)

Article Doi