149509-28-4

Upstream product

• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 13170-43-9 (trimethylsilyl)methylmagnesium chloride 
• 2344-80-1 Chloromethyltrimethylsilane 

Downstream Products

• 160709-02-4 ((3R,5R)-5-((1H-1,2,4-triazole-1-yl) methyl)-5-(2,4-difluorophenyl) tetrahydrofuran-3-yl)methanol 
• 165115-73-1 2-[2-(2,4-difluorophenyl)-2-propene-1-yl]-1, 3-propanediol 
• 192448-07-0 2-methylpropanoic acid [(2S)-4-(2,4-difluorophenyl)-2-hydroxymethyl-4-penten-1-yl] ester 
• 1350560-52-9 C₁₆H₁₉F₂IO₃ 
• 159276-62-7 diethyl 2-[2-(2,4-difluorophenyl)-2-propen-1-yl]-1,3-propanedioate 

Relevant academic research and scientific papers

Purification of Posaconazole Intermediates

The present invention relates to a process for the purification of chiral compounds, in particular to the purification of a chiral compound of formula (XI) which may be used as intermediate for the preparation of antifungal agents, preferably posaconazole.

PREPARATION OF POSACONAZOLE INTERMEDIATES

The present invention relates to process for the preparation of a chiral compound of formula (IX) or a salt thereof, wherein Y1and Y2 are independently F or C1, preferably F, the crystalline compound of formula (IX) as such, and its use for the preparation of an antifungal agent.

PURIFICATION OF POSACONAZOLE AND POSACONAZOLE INTERMEDIATES

The present invention relates to a process for the preparation of a hydrogen chloride (HC1) salt of a compound of formula (I) wherein Y1 and Y2 are independently F or C1, preferably F, said compound of formula (I) containing the cis-isomer and the trans-isomer, wherein the process comprises (1) providing the compound of formula (I) comprised in a first suitable solvent; and (2) treating the compound of formula (I) comprised in the first suitable solvent with HC1 comprised in a second suitable solvent to obtain the HC1 salt of the compound of formula (I)·

Fungicidal silicon-containing compounds and their agrochemical and medicinal uses

Compounds of formula (I): STR1 wherein: A is 1,2,4-triazol-1-yl or imidazol-1-yl; n is 0, 1, 2 or 3; X is halogen, phenyl, alkyl, haloalkyl, alkoxy, or haloalkoxy, or (X)n is alkylenedioxy; R1 is alkyl or phenyl; and R2 an