149530-63-2Relevant academic research and scientific papers
Synthesis of new 7-benzofuranmethanamines as heterocyclic analogues of the squalenepoxidase-inhibitor Butenafine
Stanetty,Koller,Purstinger,Grubner
, p. 351 - 358 (2007/10/02)
Selected title compounds (6a-f, 7a-d) were synthesized by RedAl(R)-reduction of the carboxamides 4a-f and 5a-d, easily available from the corresponding (2,3-dihydro-)7-benzofurancarboxylic acids 1a-f or 2a-d, respectively. For practical reasons, the preparation of the 2,3-dihydro-2-methyl-7-benzofuranmethanamines 6h-k with varied N-substitution by alkylation of the N-methyl-benzofuranmethanamine 6g with preformed aralkylbromides 9a-d was preferred.
