14959-31-0

Usage

Uses

Used in Pharmaceutical Industry:
N-(6-Chloro-3-pyridazinyl)acetamide is utilized as a key intermediate in the synthesis of various pharmaceutical agents and drugs. Its unique chemical structure allows it to be a building block for the development of new medications with potential therapeutic benefits.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, N-(6-Chloro-3-pyridazinyl)acetamide is employed as a compound of interest for studying its anticonvulsant properties. This research aims to develop new treatments for epilepsy and other seizure disorders, where its potential to modulate neuronal activity could provide significant clinical advantages.
Used in Oncology Research:
N-(6-Chloro-3-pyridazinyl)acetamide is also used as a subject of antitumor research. Its potential to inhibit tumor growth and affect cancer cell metabolism makes it a promising candidate for the development of novel anticancer drugs, which could lead to more effective therapies for various types of cancer.
Used in Drug Design and Development:
N-(6-Chloro-3-pyridazinyl)acetamide's structural features make it a valuable asset in drug design and development. Researchers use N-(6-Chloro-3-pyridazinyl)acetamide to create new molecular entities that can target specific biological pathways or receptors, potentially leading to more selective and effective pharmaceuticals with fewer side effects.

InChI:InChI=1/C6H6ClN3O/c1-4(11)8-6-3-2-5(7)9-10-6/h2-3H,1H3,(H,8,10,11)

Upstream product

• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 90844-35-2 3-amino-6-phenylthiopyridazine 
• 1584114-05-5 N-(6-(3-(dimethylamino)-1-phenylpropoxy)pyridazin-3-yl)acetamide 

Relevant academic research and scientific papers

Amide anions as unexpected activating groups in nucleophilic heteroaromatic substitution

Nucleophilic displacement of halide by alkoxide in pyridazines, phthalazines, a thiazole and a thiadiazole is unexpectedly activated by acetamido anion substituents compared to neutral amido and amino substituents.

Synthetic method of N-(6-chloro-3-pyridazinyl) acetamide

The invention relates to the field of organic matter synthesis and particularly discloses a synthetic method of N-(6-chloro-3-pyridazinyl) acetamide. The synthetic method comprises the following steps: taking 3-amino-6-chloropyridazine and glacial acetic acid as raw materials, wherein the ratio of 3-amino-6-chloropyridazine to glacial acetic acid is 1:(1.5-8.0); continuously conducting reaction for 5-18 hours at a temperature of 30-120 DEG C in one or two of acetonitrile, DMF, methanol, ethyl acetate, ethanol and 1,4-dioxane to generate a N-(6-chloro-3-pyridazinyl) acetamide crude product and purifying to obtain pure N-(6-chloro-3-pyridazinyl) acetamide. The synthetic method disclosed by the invention has the advantages that raw materials are easier to obtain, the price is reasonable, the reaction is mild, no special requirement for reaction equipment is made, ordinary corrosion-resistant equipment can be used for production, the reaction is easy to control, the post-treatment is simple, the product purity is high, and the popularization is easy.

THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF

The present invention relates to compounds of formula (I): (I) and salts thereof, wherein: R1-R4 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of BRG1, BRM and/or PB1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various BRG1-mediated disorders, BRM-mediated disorders and/or PB1-mediated disorders.

SUBSTITUTED 3-HETEROARYLOXY-3-(HETERO)ARYL-PROPYLAMINES AS SEROTONIN TRANSPORTER AND SEROTONIN HT2C RECEPTOR MODULATORS

The present invention relates to compounds compound according to Formula (1): and pharmaceutically acceptable salts, hydrates and solvates thereof. These compounds have serotonin (5-HT) transporter inhibitory effects and 5-HT 2C receptor antagonist or inverse agonist effects. The present invention also relates to pharmaceutical compositions comprising these compounds, and methods of using them for application in the prophylaxis or treatment of CNS disorders.