14959-31-0

Basic information

• Product Name: N-(6-Chloro-3-pyridazinyl)acetamide
• Synonyms: N-(6-Chloro-3-pyridazinyl)acetamide;N-(6-Chloro-pyridazin-3-yl)-acetaMide;3-Acetamido-6-chloropyridazine;N-(6-Chloro-3-pyridazinly)acetamide
• CAS NO: 14959-31-0
• Molecular Formula: C₆H₆ClN₃O
• Molecular Weight: 171.58434
• Mol File: 14959-31-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 250 °C (decomp)
• Boiling Point: 461.8 °C at 760 mmHg
• Flash Point: 233.1 °C
• Appearance: Colorless transparent liquid
• Density: 1.419g/cm³
• Vapor Pressure: 1.04E-08mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.01±0.70(Predicted)
• CAS DataBase Reference: N-(6-Chloro-3-pyridazinyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-Chloro-3-pyridazinyl)acetamide(14959-31-0)
• EPA Substance Registry System: N-(6-Chloro-3-pyridazinyl)acetamide(14959-31-0)

Safety Data

• Hazardous Substances Data: 14959-31-0(Hazardous Substances Data)

Usage

General Description

N-(6-Chloro-3-pyridazinyl)acetamide is a chemical compound with the molecular formula C7H7ClN2O. It is an acetamide derivative that contains a 6-chloro-3-pyridazinyl group. N-(6-Chloro-3-pyridazinyl)acetamide is commonly used in the pharmaceutical industry for the synthesis of various pharmaceutical agents and drugs. It has also been studied for its potential biological activities, including its anticonvulsant and antitumor properties. N-(6-Chloro-3-pyridazinyl)acetamide is a versatile compound that has many applications and continues to be the subject of research for its potential therapeutic uses.

InChI:InChI=1/C6H6ClN3O/c1-4(11)8-6-3-2-5(7)9-10-6/h2-3H,1H3,(H,8,10,11)

Upstream product

• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 90844-35-2 3-amino-6-phenylthiopyridazine 
• 1584114-05-5 N-(6-(3-(dimethylamino)-1-phenylpropoxy)pyridazin-3-yl)acetamide 

Relevant articles and documents

Amide anions as unexpected activating groups in nucleophilic heteroaromatic substitution

Nucleophilic displacement of halide by alkoxide in pyridazines, phthalazines, a thiazole and a thiadiazole is unexpectedly activated by acetamido anion substituents compared to neutral amido and amino substituents.

THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF

The present invention relates to compounds of formula (I): (I) and salts thereof, wherein: R1-R4 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of BRG1, BRM and/or PB1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various BRG1-mediated disorders, BRM-mediated disorders and/or PB1-mediated disorders.

Pyridazines. LI. Synthetic approaches to pyridazino(2,3-a)-1,3,5-triazines, a novel heterocyclic system.

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