149636-02-2Relevant academic research and scientific papers
Head-to-tail cyclization and use of C(α)-allyl ester protection improves the yield of cyclic peptides synthesized by the oxime resin method
Kapurniotu,Taylor
, p. 7031 - 7034 (1993)
Fully protected and C-terminal free cyclic (lactam-bridged) peptides are assembled by the oxime resin method in high yields and purity applying a four dimensional orthogonal (Boc/Bzl/Fmoc/Al) protection scheme and a head-to-tail cyclization strategy.
A novel and efficient method for cleavage of phenacylesters by magnesium reduction with acetic acid
Kokinaki, Stella,Leondiadis, Leondios,Ferderigos, Nikolas
, p. 1723 - 1724 (2007/10/03)
(Equation Presented) In the present study, we use magnesium turnings as a new deprotection reagent for the phenacyl group during orthogonal organic synthesis in the presence of other esters and sensitive protecting groups. By applying the new magnesium turnings/acetic acid deprotection method, phenacyl group can be more easily combined with other protecting groups that are not compatible with the zinc/acetic acid method.
