Head-to-tail cyclization and use of C(α)-allyl ester protection improves the yield of cyclic peptides synthesized by the oxime resin method

Article abstract of DOI:10.1016/S0040-4039(00)61589-7

Fully protected and C-terminal free cyclic (lactam-bridged) peptides are assembled by the oxime resin method in high yields and purity applying a four dimensional orthogonal (Boc/Bzl/Fmoc/Al) protection scheme and a head-to-tail cyclization strategy.