1496532-92-3

Upstream product

• 1496532-91-2 4-bromo-3-(2,5-dihydro-4-formyl-1-tosylpyrrol-2-yl)methyl-1-tosylindole 
• 913484-72-7 N-(2-hydroxy-but-3-ynyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Formal synthesis of (±)-cycloclavine

An efficient formal synthesis of (±)-cycloclavine is achieved in seven steps and 27% overall yield from the known 2-(4-bromo-1-tosyl-1H-indol-3- yl)acetaldehyde. Key features include an iron(III)-catalyzed aza-Cope-Mannich cyclization and an intramolecular Heck reaction or a self-terminating 6-exo-trig aryl radical-alkene cyclization.