1496532-91-2Relevant academic research and scientific papers
Formal synthesis of (±)-cycloclavine
Wang, Wei,Lu, Jia-Tian,Zhang, Hao-Li,Shi, Zi-Fa,Wen, Jing,Cao, Xiao-Ping
, p. 122 - 127 (2014)
An efficient formal synthesis of (±)-cycloclavine is achieved in seven steps and 27% overall yield from the known 2-(4-bromo-1-tosyl-1H-indol-3- yl)acetaldehyde. Key features include an iron(III)-catalyzed aza-Cope-Mannich cyclization and an intramolecular Heck reaction or a self-terminating 6-exo-trig aryl radical-alkene cyclization.
