1496532-96-7

Upstream product

• 1273005-83-6 2-(4-bromo-1-tosyl-1H-indol-3-yl)acetaldehyde 
• 882-33-7 diphenyldisulfane 
• 913484-72-7 N-(2-hydroxy-but-3-ynyl)-4-methylbenzenesulfonamide 

Downstream Products

• 1496532-95-6 1,6-ditosyl-8-methyl-4,5,6,7-tetrahydroindolo[4,3-ef]indole 

Relevant academic research and scientific papers

Formal synthesis of (±)-cycloclavine

An efficient formal synthesis of (±)-cycloclavine is achieved in seven steps and 27% overall yield from the known 2-(4-bromo-1-tosyl-1H-indol-3- yl)acetaldehyde. Key features include an iron(III)-catalyzed aza-Cope-Mannich cyclization and an intramolecular Heck reaction or a self-terminating 6-exo-trig aryl radical-alkene cyclization.