149656-42-8Relevant academic research and scientific papers
The Isolation and Structure Elucidation of Zaragozic Acid C, a Novel Potent Squalene Synthase Inhibitor
Dufresne, Claude,Wilson, Kenneth E.,Zink, Deborah,Smith, Jack,Bergstrom, James D.,et al.
, p. 10221 - 10226 (1992)
The novel zaragozic acid C (1) has been isolated as a potent inhibitor of squalene synthase.It was found to be a competitive inhibitor of rat liver squalene synthase with an apparent Ki of 45 +/- 15 pM, and a broad spectrum antifungal agent against both yeast and filamentous fungi.
