Tetrahedron p. 10221 - 10226 (1992)
Update date:2022-08-03
Topics:
Dufresne, Claude
Wilson, Kenneth E.
Zink, Deborah
Smith, Jack
Bergstrom, James D.
et al.
The novel zaragozic acid C (1) has been isolated as a potent inhibitor of squalene synthase.It was found to be a competitive inhibitor of rat liver squalene synthase with an apparent Ki of 45 +/- 15 pM, and a broad spectrum antifungal agent against both yeast and filamentous fungi.
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