The Isolation and Structure Elucidation of Zaragozic Acid C, a Novel Potent Squalene Synthase Inhibitor

DOI: 10.1016/S0040-4020(01)88327-7

Source and publish data:

Tetrahedron p. 10221 - 10226 (1992)

Update date:2022-08-03

Topics:

Authors:

Dufresne, Claude

Wilson, Kenneth E.

Zink, Deborah

Smith, Jack

Bergstrom, James D.

et al. et al.

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Article abstract of DOI:10.1016/S0040-4020(01)88327-7

The novel zaragozic acid C (1) has been isolated as a potent inhibitor of squalene synthase.It was found to be a competitive inhibitor of rat liver squalene synthase with an apparent K_i of 45 +/- 15 pM, and a broad spectrum antifungal agent against both yeast and filamentous fungi.

Full text of DOI:10.1016/S0040-4020(01)88327-7

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